On March 25, 2021 Propanc Biopharma, Inc. (OTCQB: PPCB) ("Propanc" or the "Company"), a biopharmaceutical company developing novel cancer treatments for patients suffering from recurring and metastatic cancer, reported that its Chief Executive Officer, Mr. James Nathanielsz, provided a description of future target milestones and an update as the Company’s lead product candidate, PRP, advances towards a Phase IB, First-In-Human (FIH) study in advanced cancer patients suffering from solid tumors. Mr. Nathanielsz also highlighted the Company’s strategic objectives to evaluate possible pipeline expansion opportunities, as it looks to transform into a clinical stage, immuno-oncology player targeting metastatic cancer from solid tumors. Any potential acquisition would be considered a novel, first in class therapy, potentially further enhanced by PRP, which has the ability to penetrate and alter the tumor micro-immune environment and therefore make once resistant and impenetrable tumors susceptible to other approaches, like CAR-T therapy, which may be a novel approach to target and treat solid tumors.
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"As we progress further into 2021, our management team continues to work on advancing PRP to a FIH study, but also focusing on strategic objectives which can leverage our capabilities, fast track growth and offer potentially exciting new possibilities for the way we treat advanced cancer patients suffering with solid tumors. We feel the challenges of last year as a result of the global pandemic appear to be behind us and optimism in the biotech sector remains robust," said Mr. Nathanielsz. "Therefore, we intend to capitalize on this current environment and look to fast track the growth of our Company by potentially identifying exciting new therapeutic candidates which are IND (Investigational New Drug) ready."
Upcoming milestones
PRP:
Completion of remaining process development activities, subsequent engineering run and full scale GMP manufacture of PRP in preparation for a FIH study in advanced cancer patients;
Completion of the validation of the bioanalytical method for the FIH study.
Preparation of the Investigational Medicinal Product Dossier (IMPD), as part of a clinical trial application (CTA) for a FIH study, to be submitted at the Peter Mac Center, in Melbourne, Australia.
POP1 Joint Research & Drug Discovery Project:
Expanding the pipeline through production of biological compounds that mimic the action of proenzymes, whilst minimizing variation between different lots and without the use of animals as the primary source of materials. The Company’s researchers are currently optimizing conditions to extract high titers of the active materials before further analysis determining whether they are producing the right quality compounds.
Management Highlights:
Mr. Nathanielsz and the Propanc management team are evaluating possible pipeline expansion opportunities that complements its existing technology, which can potentially halt aggressively spreading tumors and prevent tumor niche formation, therefore possibly further enhancing the response rate of a new drug candidate. Potential candidates will have advanced towards IND ready stage, are innovative with a significant advantage over the competition, and where the Propanc management team can fast track development milestones and commercialization to realize value for investors.