On August 16, 2022 Propanc Biopharma, Inc. (OTCQB: PPCB) ("Propanc" or the "Company"), a biopharmaceutical company developing novel cancer treatments for patients suffering from recurring and metastatic cancer, reported that a Notice of Allowance has been received from the European Patent Office (EPO) for claims involving compositions of proenzymes to treat cancer (Press release, Propanc, AUG 16, 2022, View Source [SID1234618430]). This is the Company’s second patent application allowed in this jurisdiction and expires in November, 2036. A third patent application is currently under examination at the EPO for a method to treat cancer stem cells, which was allowed in March this year by the US Patent and Trademark Office (USPTO).

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The field of the invention covers future dosing in planned clinical studies for the Company’s lead product candidate, PRP. The allowed patent, citing proenzyme compositions to treat cancer, comprising trypsinogen and chymotrypsinogen at specific higher dosage ratios than the Company’s original foundation patent, will enable the Company to cover higher doses in a planned, Phase I, First-In-Human study in advanced cancer patients. It is believed that increased exposure at higher doses may result in better therapeutic efficacy.

Currently, the Company’s growing IP portfolio consists of 65 patents either in force, or currently under examination in global jurisdictions. As a result of the EPO allowance, the number of patents in the portfolio is expected to increase as the Company validates the allowed patent in selected individual countries within the EU region. The Company also plans to file additional patent applications based on recent scientific discoveries through the Company’s joint research partnerships in the near future, centered on composition, method of use and process development claims.

"The advancement of our growing IP portfolio is a reflection of our tireless efforts over the last decade into research and development of proenzymes as an effective tool to treat cancer," said Mr. James Nathanielsz, Propanc’s Chief Executive Officer. "As we progress towards a First-In-Human study in advanced cancer patients, it is important to ensure adequate protection of our invention, which holds significant value for shareholders, as we continue to expand in this novel field. PRP is an exciting new approach to treat and prevent metastatic cancer by targeting and eradicating cancer stem cells (CSCs), which remains the biggest cause of death for sufferers. By targeting CSCs and leaving healthy cells alone, it may also be free from the side effects normally associated with standard treatments, which will be significant for patients and their loved ones. We remain dedicated to this cause."

PRP is a mixture of two proenzymes, trypsinogen and chymotrypsinogen from bovine pancreas administered by intravenous injection. A synergistic ratio of 1:6 inhibits growth of most tumor cells. Examples include kidney, ovarian, breast, brain, prostate, colorectal, lung, liver, uterine and skin cancers.