On January 21, 2019 RadioMedix Inc. is reported that the company has been awarded a two-year, $2.0 M Phase II SBIR contract award by the NIH NCI (HHSN261201800048C; UPIID:75N91018C00048) for the clinical development of Targeted Alpha-emitter Therapy (TAT) of neuroendocrine tumors (Press release, RadioMedix, JAN 21, 2019, View Source [SID1234532801]). This Phase II Contract award is a continuation of the successfully completed Phase I SBIR contract (HHSN261201600015C). This award will support the Phase I, non-randomized, open-label, dose escalation study to determine the safety, bio-distribution, and preliminary effectiveness of 212Pb-octreotate analog (AlphaMedix) in adult subjects with Somatostatin Receptor (SSTR) expressing neuroendocrine tumors (NCT03466216). Dr. Izabela Tworowska (RadioMedix) serves as a Principal Investigator of the SBIR Phase II contract and is working together with Dr. Julien Torgue (co-I, Orano Med). The clinical studies are currently on-going at the Excel Diagnostics and Nuclear Oncology Center (Houston, TX).
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"Patients with advanced Neuroendocrine Tumors (NETs) have limited treatment options available to them. Our goal is to address this unmet clinical need by using targeted alpha-emitter therapy", said Izabela Tworowska, PhD, CSO of RadioMedix. "We are grateful to NCI for acknowledging the importance of alpha-emitter therapy and supporting our clinical studies of 212Pb-octreotate analog. This SBIR Phase II Contract is the second award highlighting RadioMedix – Orano Med collaboration."
"TAT is believed to be the next generation of radiopharmaceuticals in the field of Radioligand Therapy (RLT) in oncology. Our proprietary 212Pb labeled agent has potential to advance the effectiveness of Peptide Receptor Radionuclide therapy (PRRT) as compared to currently approved PRRT agents for neuroendocrine cancers", said Dr. Ebrahim S. Delpassand, CEO of RadioMedix. "Unique properties of 212Pb can induce targeted and irreversible damage to the cancer cells, which can result in significant clinical benefits to NET patients", added Dr. Delpassand.
This project has been funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN261201800048C.