On September 13, 2021 Sapience Therapeutics, Inc., a biotechnology company focused on the discovery and development of peptide therapeutics to address difficult-to-treat cancers, reported that it will present a poster on its lead program, ST101, at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress 2021, being held September 16-21, 2021 (Press release, Sapience Therapeutics, SEP 13, 2021, View Source [SID1234587640]). The e-poster will be available to meeting attendees on September 16, 2021 and will be available on the Sapience website following the conclusion of ESMO (Free ESMO Whitepaper).
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Poster presentation details are as follows:
Presentation Title: Efficacy, safety, pharmacokinetic (PK) and pharmacodynamic (PD) data from phase 1 dose escalation of a novel therapeutic peptide, ST101, targeting the oncogenic transcription factor C/EBPβ, in patients (pts) with advanced and metastatic solid tumors
Presentation Number: #525P
About ST101
ST101, a peptide antagonist of C/EBPβ, is currently being evaluated in an ongoing Phase 1-2 clinical study in patients with advanced unresectable and metastatic solid tumors (NCT04478279). In the ongoing study, ST101 has demonstrated clinical proof-of-concept with a RECIST 1.1-confirmed partial response (PR) in a patient with cutaneous melanoma and evidence of long-lasting stable disease in several additional patients. Following conclusion of the final dose-escalation cohort, Sapience plans to initiate four Phase 2 expansion cohorts in refractory, locally advanced and metastatic cutaneous melanoma, hormone-receptor-positive breast cancer, castrate-resistant prostate cancer, and glioblastoma starting in the second half of 2021. ST101 has been granted orphan drug product designation from the U.S. Food and Drug Administration and orphan medicinal product designation for the treatment of glioma by the European Commission.