On August 24, 2021 Seneca Therapeutics, Inc., a clinical-stage biopharmaceutical company dedicated to the development of oncolytic immune-therapeutics based on Seneca Valley Virus (SVV-001), reported the issuance and allowance of several U.S. patents for TEM8 (also known as ANTXR1) licensed from Memorial Sloan Kettering Cancer Center (MSK) (Press release, Seneca Therapeutics, AUG 24, 2021, View Source [SID1234586851]). TEM8 may enable pre-screening of solid tumors to determine if SVV-001 might be effective in that patient. This discovery is based on research from Charles Rudin, MD, PhD., Chief, Thoracic Oncology Service at MSK and his team.
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U.S. Patent No. 11,096,972 B2 for Seneca valley virus (SVV) cellular receptor targeted oncotherapy, was issued today by the U.S. Patent Office. This patent covers combination therapies with Seneca Valley Virus (SVV) in patients who have a normal or an elevated expression level of ANTXR1 and a decreased expression level of IFN-I in a cancerous tissue.
That patent follows U.S. Patent No. 10,537,599 B2 for Seneca valley virus (SVV) cellular receptor targeted oncotherapy which issued on January 21, 2020 and broadly covers methods for treating cancer, comprising: determining an expression level of anthrax toxin receptor 1 (ANTXR1) in a cancerous tissue from a patient, and administering to the patient an effective amount of Seneca Valley Virus (SVV) if a normal expression level or an elevated expression level of ANTXR1 is detected in the cancerous tissue.
Patent applications protecting these inventions are also pending throughout the world in Europe, China, Australia, Canada, Israel and India. This adds to the growing body of issued intellectual property that broadly covers SVV, SVV analogues, and methods of killing cancer cells using SVV and related analogues, to which Seneca Therapeutics owns exclusive rights.
Dr. Paul Hallenbeck, Founder, President, and Chief Scientific Officer at Seneca Therapeutics commented "We are very pleased with the progress of these patents in the U.S. Patent Office. Our exclusive license to these patents, with rights to sublicense, will help to maintain Seneca Therapeutics’ leadership in treating cancers using SVV."