On October 23, 2023 Sensei Biotherapeutics, Inc. (Nasdaq: SNSE), a clinical stage immuno-oncology company focused on the discovery and development of next-generation therapeutics for cancer patients, reported a trial-in-progress poster from the Phase 1/2 clinical trial for SNS-101, a conditionally active, human monoclonal antibody targeting the immune checkpoint VISTA (V-domain Ig suppressor of T cell activation), at the European Society for Medical Oncology Congress (ESMO) (Free ESMO Whitepaper) 2023 (Press release, Sensei Biotherapeutics, OCT 23, 2023, View Source [SID1234636261]).

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The multi-center Phase 1/2 clinical trial is a first-in-human, open-label, dose escalation study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of SNS-101 as both a monotherapy and in combination with Regeneron’s PD-1 inhibitor Libtayo in patients with advanced solid tumors. To date, four patient cohorts have been enrolled in the monotherapy arm. Sensei expects to report initial pharmacokinetic and safety monotherapy data in the fourth quarter of 2023, and topline monotherapy data in 2024. The company has also initiated the combination arm of the study and expects to report initial combination safety and pharmacokinetic data in the first quarter of 2024, with preliminary anti-tumor activity combination data in 2024.

The full poster is available for viewing on Sensei’s website in the "Events & Presentations" section of the Company’s Investor Relations website at www.senseibio.com.