On May 15, 2020 Silverback Therapeutics ("Silverback"), a biopharmaceutical company advancing a pipeline of therapies that are systemically delivered, but locally active, reported that preclinical data supporting development of its lead ImmunoTAC candidate, SBT6050, has been accepted for presentation at two upcoming oncology meetings (Press release, Silverback Therapeutics, MAY 15, 2020, View Source [SID1234558166]). SBT6050 is a HER2-directed monoclonal antibody conjugated to a potent and highly specific TLR8 agonist that drives tumor-localized activation of myeloid cells. In preclinical models, activation of myeloid cells results in single agent anti-tumor immune responses, even in tumors lacking T cells. These data will be featured in virtual poster sessions at ASCO (Free ASCO Whitepaper)20 Virtual Scientific Program and AACR (Free AACR Whitepaper) 2020 Virtual Annual Meeting.

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ASCO20 Virtual Scientific Program

Title: SBT6050, a HER2-Directed TLR8 Therapeutic, is a Systemically Administered, Tumor-Targeted Human Myeloid Cell Agonist
Abstract ID: 3110
Presenter: Valerie Odegard, PhD, CSO
Virtual Presentation: Available online starting May 29, 2020 at 8:00 A.M. ET

AACR Virtual Annual Meeting 2020 Session II

Title: SBT6050, a HER2-Directed TLR8 ImmunoTAC Therapeutic, is a Potent Human Myeloid Cell Agonist that Provides Opportunity for Single Agent Clinical Activity
Abstract ID: 1523
Presenter: Valerie Odegard, PhD, CSO
Virtual Presentation: Available online starting June 22 at 9:00 A.M. ET