On October 22, 2024 SOTIO Biotech, a clinical-stage immuno-oncology company owned by PPF Group, reported it will present three posters at the 2024 Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Meeting taking place November 6 – 10, 2024, in Houston, TX (Press release, SOTIO, OCT 22, 2024, View Source [SID1234647323]).

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Data to be presented include the investigation of a novel chimeric PGC-1α transgene to enhance CAR T cell efficacy in patients with solid tumors. The VICTORIA-01 study is currently evaluating the safety, tolerability and initial efficacy of SOT201 monotherapy for the treatment of advanced solid tumors, as well as data around SOT201, a next-generation clinical stage PD-1-targeting immunocytokine.

Poster details are as follows:

Title: "Chimeric PGC-1α expression in CAR-T cells improves metabolic function and anti-tumor efficacy in solid tumors"
Abstract Number: 273
Date: Thursday, November 7 and Friday, November 8, 2024
Presenting Author: Amy Jensen-Smith

Title: "VICTORIA-01: A multicenter, open-label, phase 1 study to evaluate the safety and preliminary efficacy of SOT201 in patients with advanced or metastatic solid tumors"
Abstract Number: 675
Date: Friday, November 8, 2024
Presenting Author: Aung Naing

Title: "SOT201, a novel cis-acting PD-1/IL-15 mutein-based immunocytokine that reinvigorates anti-tumor immunity qualitatively superior to PD-1/IL-2v-based IL-2/15Rβγ agonism"
Abstract Number: 940
Date: Saturday, November 9, 2024
Presenting Author: Irena Adkins