On October 17, 2023 STORM Therapeutics Ltd. (STORM), a clinical stage biotechnology company discovering and developing novel small molecule therapies targeting RNA modifying enzymes (RMEs) for oncology and other diseases, reported that Dr. Yaara Ofir-Rosenfeld, Director of Translational Oncology at STORM, presented novel pre-clinical data investigating the combination of METTL3 inhibitors (METTL3i) with DNA damaging therapies at the AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper) in Boston, Massachusetts on the 11-15 October 2023 (Press release, STORM Therapeutics, OCT 17, 2023, View Source [SID1234636082]).
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The presentation entitled "STC-15, a small molecule inhibitor of the RNA methyltransferase METTL3, activates anti-tumor immunity and reshapes the tumor microenvironment" detailed pre-clinical findings from STORM’s investigational drug STC-15 in combination with DNA damaging therapies. STC-15 is an orally bioavailable, highly selective METTL3 inhibitor and is the first molecule specifically targeting an RNA methyltransferase enzyme to enter clinical development.
STORM’s new data demonstrates that:
METTL3 inhibition enhances cytotoxicity of DNA damaging chemotherapies such as doxorubicin
Combination of STC-15 with chemotherapies activates cancer cell intrinsic interferon signalling that contributes to the induction of immunogenic cell death.
STC-15 synergises with radiation therapy in vivo
STC-15 reshapes the tumor microenvironment, shifting it from an immunosuppressive, pro-tumorigenic to an immune stimulatory, anti-tumor state
A first-in-human clinical trial on STORM’s lead clinical candidate STC-15 in patients with solid tumours is ongoing and can be found on clinicaltrials.gov under the identifier NCT05584111.
Yaara Ofir-Rosenfeld, Director of Translational Oncology of STORM Therapeutics, added, "Many tumours develop mechanisms that suppress their recognition by the immune system and limit their response to treatment. Our new findings reveal that STC-15 treatment shifts the tumour microenvironment to an immunostimulatory state and thereby boosts the efficacy of established cancer treatments such as radio- and chemotherapy."
Oliver Rausch, Chief Scientific Officer of STORM Therapeutics, commented, "These exciting new data build on our previous findings that STC-15 leads to activation of anti-tumor immunity and tumor killing. They illustrate a huge opportunity for STC-15 to be combined with a wide range of existing standard of care cancer drugs including checkpoint inhibitors and DNA damaging agents. This represents a major discovery for the STORM team as we look to develop STC-15 as a novel treatment option for cancer patients."
Details of the conference and presented abstract are as follow:
Abstract Title: STC-15, a small molecule inhibitor of the RNA methyltransferase METTL3, activates anti-tumor immunity and reshapes the tumor microenvironment
Presenter: Yaara Ofir-Rosenfeld1
Date and Time: Saturday, 14 October 2023, 12:30pm-4:00pm EDT
Location: Level 2, Exhibit Hall D
Poster number: C077
Session: Poster Session C
1STORM Therapeutics Ltd., Cambridge, UK