On September 11, 2020 Sumitomo Dainippon Pharma Oncology, Inc., a developer of novel cancer therapeutics, reported that new data evaluating the oral investigational agent dubermatinib (TP-0903), an AXL kinase inhibitor, will be presented at the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) 2020 Virtual Annual Congress, being held September 19-21, 2020 (Press release, Sumitomo Dainippon Pharma, SEP 11, 2020, View Source [SID1234565037]). Data will be shared during the Developmental Therapeutics Mini-Oral Presentation and include findings from a Phase 1 study evaluating the safety, pharmacokinetics, pharmacodynamics and clinical activity of dubermatinib in patients with advanced solid tumors.
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"We are pleased to present these new data to the scientific community at ESMO (Free ESMO Whitepaper) 2020, which build upon our growing understanding of dubermatinib and the potential role of AXL kinase inhibition in oncology," said David J. Bearss, Ph.D., Chief Scientific Officer and Global Head of Research, Sumitomo Dainippon Pharma Oncology (SDP Oncology). "Furthermore, we look forward to sharing the findings from the expansion arms of the Phase 1 study evaluating the role dubermatinib may play in the treatment of specific tumor types. These data also represent SDP Oncology’s commitment to advancing purposeful science in emerging areas of oncology research that aims to positively impact outcomes for patients with cancer."
Below are the details for the SDP Oncology presentation:
Abstract Title
Details
Presenter
A Phase 1, First-in-human, Safety, Pharmacokinetic, and Pharmacodynamic Study of Oral Dubermatinib (TP-0903) in Patients with Advanced Solid Tumors
Presentation #536MO
Friday, September 18 at 9:56 a.m. CEST
Mini-Oral Presentation
John Sarantopoulos, M.D., UT Health San Antonio
About Dubermatinib (TP-0903)
Dubermatinib is an investigational oral AXL receptor tyrosine kinase (RTK) inhibitor under evaluation in a Phase 1a/b study in patients with advanced solid tumors (NCT02729298) and an ongoing study in collaboration with the Leukemia & Lymphoma Society as part of the Beat AML Clinical Trial (NCT03013998). SDP Oncology is exploring parallel clinical development paths for dubermatinib in both solid and hematologic malignancies.
About AXL Kinase
AXL belongs to the TAM (Tyro3, AXL and Mer) family of receptor tyrosine kinases and is overexpressed in many human cancers.1 It plays a key role in tumor cell proliferation, survival, metastasis, cellular adhesion, and avoidance of the immune response. The overexpression of AXL is associated with a poor patient prognosis and drug resistance.2