On May 22, 2023 Therapeutic Solutions International (TSOI) reported that its Spin-Off Company, Res Nova Bio, achieved successful delivery of a cancer killing virus to breast cancer, resulting in shrinkage of the tumor without induction of side effects (Press release, Res Nova Bio, MAY 22, 2023, View Source [SID1234631936]).
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The Company, which is currently manufacturing the FDA-cleared ValloVax endothelial cell vaccine, has demonstrated that intravenous administration of viral infected ValloVax cells results in direct delivery to the breast cancer, causing regression and generation of immunity. The company plans to generate "next generation" tumor targeting cell therapies based on specific properties of the blood vessels that feed the cancer.
"Cancer cells are selectively sensitive to killing by viruses because in their decision to multiply excessively and metastasize, they forgo antiviral molecular defenses that are present in non-cancer cells," said Dr. James Veltmeyer, Chief Medical Officer. "The FDA has approved one viral derived product, T-Vec by Amgen for treatment of melanoma, however this requires injection directly into the tumor, which has some level of impracticality since not all tumors can be accessed1. The data presented today provides a means of intravenously delivering the virus using cells that selectively deliver it to cancer blood vessels."
ValloVax was cleared by the FDA for a clinical trial for treatment of lung cancer2, and detailed scientific mechanisms of its ability to selectively interact with new tumor blood vessels has been published3. Res Nova Bio collaborates with the Veltmeyer Institute to provide access to ValloVax to no option breast cancer patients4.
"I commend CEO Famela Ramos and her team of collaborators at Res Nova for expanding the "pregnancy-cancer" connection into the area of oncolytic virus delivery, which opens numerous doors for therapeutic possibilities and partnerships," stated Timothy Dixon, President, and CEO of Therapeutic Solutions International, the company from which Res Nova spun-out of. "It is important to remember that the virus used in these studies, Newcastle Disease Virus, is well characterized and has a very favorable safety profile, making this an ideal "proof-of-concept" experiment.
"The focus of Res Nova is finding a cure for breast cancer. We see this new data as providing a potentially new weapon in the armamentarium of the brave clinicians who are waging war against this merciless killer," said Famela Ramos, President, and CEO of Res Nova.