On November 8, 2022 Turnstone Biologics Corp, a clinical-stage biotechnology company developing next-generation immunotherapies to treat and cure solid tumors, reported that two posters showing preclinical data from the Company’s novel tumor-infiltrating lymphocyte (TIL) therapy will be presented at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 37th Annual Meeting, being held in Boston, Massachusetts, November 8-12, 2022 (Press release, Turnstone Biologics, NOV 8, 2022, View Source [SID1234623438]).

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The posters, one of which is to be presented in collaboration with Moffitt Cancer Center, will showcase data demonstrating the successful expansion and enrichment of tumor-reactive TILs from colorectal cancer tumor samples, providing support for the application of TIDAL-01 as a therapy for solid tumors. TIDAL-01, Turnstone’s lead TIL therapy candidate, focuses on selecting and manufacturing the most potent tumor-reactive T-cells (Selected TILs) to overcome the limitations of current TIL-based therapies.

"Over the years, we have witnessed remarkable durable responses in a limited number of solid tumor types following treatment with TILs," said Stewart Abbot, Ph.D., Chief Scientific Officer, Turnstone Biologics. "Our preclinical datasets demonstrate greater promise for our Selected TILs compared to conventional TIL-based therapies to target a broader range of solid tumors. With our recently accepted INDs for TIDAL-01, we are eager to translate these promising results into the clinic, including through our strategic alliance with Moffitt."