On November 3, 2022 Wugen, Inc., a clinical-stage biotechnology company developing a pipeline of allogeneic cell therapies to treat a broad range of hematological and solid tumor malignancies, reported an upcoming presentation highlighting key features of WU-NK-101, the company’s lead memory natural killer (NK) cell therapy product, that support its application for the treatment of relapsed/refractory (R/R) acute myelogenous leukemia (AML) and elucidate predictors of therapeutic response to cytokine-induced memory-like (CIML) NK cell therapy (Press release, Wugen, NOV 3, 2022, View Source [SID1234623028]). The data will be presented at the 64th Annual Meeting of the American Society of Hematology (ASH) (Free ASH Whitepaper) taking place December 10 – 13, 2022 in New Orleans, Louisiana.
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Compared to conventional NK cells, WU-NK-101 demonstrated enhanced trafficking to the bone marrow, robust anti-tumor activity, and an adaptive metabolic profile consistent with aerobic glycolysis, which may support resilience in an immunosuppressive tumor microenvironment (TME). Together, these data demonstrate WU-NK-101 may represent an effective treatment modality for R/R AML.
Further analysis also identified an 8-gene TME signature score that was significantly higher at baseline in patients with R/R AML that responded to CIML NK cell therapy. The TME signature also correlated with response duration.
The details of Wugen’s presentation at ASH (Free ASH Whitepaper) are as follows:
Title: Putative Predictors of Response to WU-NK-101, an Allogeneic, Enhanced Memory (ML)
Natural Killer (NK) Cell Therapy Product, for Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)
Publication Number: 3294
Session Name: 703. Cellular Immunotherapies: Basic and Translational: Poster II
Session Date and Time: Sunday, December 11, 2022 from 6:00 p.m. – 8:00 p.m. CT
Location: Ernest N. Morial Convention Center, Hall D
Presenting Author: Sergio Rutella, M.D., Ph.D., FRCPath, FRSB, Nottingham Trent University
Additional meeting information can be found at View Source
About WU-NK-101
WU-NK-101 is a novel immunotherapy harnessing the power of memory natural killer (NK) cells to treat liquid and solid tumors. Memory NK cells are hyper-functional, long-lasting immune cells that exhibit enhanced anti-tumor activity and a cytokine-induced memory-like (CIML) phenotype. This rare cell population has a superior phenotype, proliferation capacity, and metabolic fitness that makes it better suited for cancer therapy than other NK cell therapies. Wugen is applying its proprietary Moneta platform to advance WU-NK-101 as a commercially scalable, off-the-shelf cell therapy for cancer. WU-NK-101 is currently in development for acute myelogenous leukemia (AML) and solid tumors.