On March 14, 2023 Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, reported it will present preclinical data on novel XmAb CD28 bispecific antibody programs at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, being held April 14-19, 2023 at the Orange County Convention Center in Orlando, Florida (Press release, Xencor, MAR 14, 2023, View Source [SID1234628686]).
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"T cells in the tumor microenvironment require engagement of their T cell receptor (TCR) and their co-stimulatory receptors like CD28 to achieve full activation. This is diminished in cancer because tumor cells usually do not express CD28 ligands. We have developed an XmAb antibody platform that allows for the rapid generation of drug candidates that co-stimulate CD28 only in the presence of tumor cells and TCR engagement," said John Desjarlais, Ph.D., senior vice president and chief scientific officer at Xencor. "We are using the platform to explore the universe of solid tumor targets, and at AACR (Free AACR Whitepaper) we will present data on candidates targeting CEACAM5, mesothelin, STEAP1 and Trop-2, which have broad applicability across a range of solid tumors."
Poster Presentation Details
Abstract 2983, "Tumor-specific CD28 costimulatory bispecific antibodies enhance T cell activation in multiple solid tumors"
Session: Immunology – Therapeutic Antibodies 3
Date and Time: Monday, April 17, 2023, 1:30 p.m. – 5:00 p.m. EDT
Location: Poster Section 24, Board Number 30
Abstracts are available on AACR (Free AACR Whitepaper)’s website located at www.aacr.org. Posters will be archived under "Events & Presentations" in the Investors section of the Company’s website located at www.xencor.com.