On March 28, 2017 XOMA Corporation (Nasdaq:XOMA), a pioneer in the discovery and development of therapeutic antibodies, reported the presentation of data from its PTH1R Monoclonal Antibodies Program (Press release, Xoma, MAR 28, 2017, View Source [SID1234518318]). The poster, which reports data from a pre-clinical study investigating the efficacy of the Company’s anti-PTH1R antagonist monoclonal antibody in reversing hypercalcemia, will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) annual meeting, April 1-5, 2017, in Washington, DC.
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Hypercalcemia is relatively common in patients with cancer, occurring in up to 30 percent of casesi. Hypercalcemia often occurs in patients with both solid tumors and hematologic malignancies due to release of a protein that activates the parathyroid hormone receptor (PTH1R) thereby leading to potentially dangerous calcium levels. Malignancy often is evident clinically by the time it causes hypercalcemia, and those patients often have a poor prognosis.
“Our PTH1R program began as an endocrine program, but because of its unique mechanism-of-action we believe it is also potentially beneficial to oncology patients suffering from hypercalcemia,” said Jim Neal, Chief Executive Officer of XOMA. “We seek partners who have a deep commitment to and expertise in drug development. We believe our PTH1R program could join the other antibodies in our extensive licensing portfolio of fully funded programs that are being advanced by partner companies to benefit patients suffering from a wide range of health conditions.”
Poster Presentation Details
Abstract Title: Impacting Humoral Hypercalcemia of Malignancy (HHM) and associated PTH1R-mediated morbidities: Characterization of an anti-PTH1R antagonist monoclonal antibody to reverse hypercalcemia
Session: Late-Breaking Research (LB-306): Experimental and Molecular Therapeutics 2
Date: Wednesday, April 5, 2017, 8:00am to 12:00pm ET
Location: Poster Section 34, Board 14
For additional information, please visit the AACR (Free AACR Whitepaper) website: www.aacr.org.
About XOMA’s PTH1R Monoclonal Antibodies Program
XOMA has developed several unique functional antibody antagonists targeting PTH1R, a G-protein-coupled receptor involved in the regulation of calcium metabolism. These antibodies have shown promising efficacy in in vivo studies and potentially could address high unmet medical needs, including primary hyperparathyroidism (PHPT) and humoral hypercalcemia of malignancy (HHM).
HHM is present in many advanced cancers and is caused by high serum calcium due to increased levels of the PTH1R ligand PTH-related peptide (PTHrP). Since current HHM treatments often fall short and many cancer patients die from ‘metabolic death’, PTH1R antibodies could prove beneficial for the treatment of HHM.