On February 23, 2017 Zymeworks Inc. ("Zymeworks"), a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation multifunctional biotherapeutics, initially focused on the treatment of cancer, reported that it has submitted an abstract for the 2017 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) ("ASCO") annual meeting that contains preliminary Phase 1 data from the ZW25 Phase 1 clinical trial for treatment of HER2-expressing tumors (Press release, Zymeworks, FEB 23, 2017, View Source [SID1234517817]). Schedule your 30 min Free 1stOncology Demo! "Two of the three cohorts from the dose escalation portion of the ZW25 Phase 1 clinical trial have been fully enrolled and preliminary data has been received for those patients," said Ali Tehrani, Ph.D., Zymeworks’ President & CEO. "ZW25 is being evaluated for safety, as well as preliminary anti-tumor activity, and we are pleased to have been able to compile these results and submit them for presentation at this year’s ASCO (Free ASCO Whitepaper) annual meeting."
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The 2017 ASCO (Free ASCO Whitepaper) annual meeting will be held June 2nd through June 6th in Chicago, Illinois. The ASCO (Free ASCO Whitepaper) annual meeting brings together more than 30,000 oncology professionals from around the world to discuss state-of-the-art treatment modalities, new therapies and ongoing developments in the field of oncology. Abstracts will be released to the public on May 17th at 5:00 P.M. EDT and made available on ASCO (Free ASCO Whitepaper)’s website.
About ZW25
ZW25 is Zymeworks’ lead product candidate currently being evaluated in an adaptive Phase 1 clinical trial in the United States, based on our Azymetric platform. It is a bispecific antibody that can simultaneously bind two non-overlapping epitopes, known as biparatopic binding, of HER2 resulting in dual HER2 signal blockade, increased binding and removal of HER2 protein from the cell surface, and enhanced effector function. These combined mechanisms of action have led to significant anti-tumor activity in preclinical models. We are developing ZW25 as a best-in-class HER2-targeting antibody intended as a treatment option for patients with any solid tumor that expresses HER2.