On November 8, 2017 CERENIS Therapeutics (FR0012616852 – CEREN – PEA PME eligible) (Paris:CEREN) an international biopharmaceutical company dedicated to the discovery and development of HDL-based innovative therapies for treating cardiovascular and metabolic diseases, reported the acquisition of LYPRO Biosciences assets, a portfolio of proprietary drug delivery nanotechnology (Press release, Cerenis Therapeutics, NOV 8, 2017, View Source [SID1234522017]). The operation positions CERENIS at the forefront of the chemotherapy drug delivery and immuno-oncology space. This represents a significant step towards the Company’s strategic objective of developing the next generation of multiple targeted drug delivery nanotechnologies associated with HDL therapy.

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Financial terms of the LYPRO Biosciences assets acquisition by CERENIS Therapeutics are not disclosed. LYPRO will receive single digit regulatory milestones as well as single digit royalties depending on products sales each year.

Jean-Louis Dasseux, CEO of CERENIS Therapeutics, commented: "We are thrilled to add the LYPRO technology development program and nanotechnology platform to our portfolio of world-class HDL assets. Building on the strong foundation of our lead HDL product, CER-001, this acquisition opens another therapeutic area characterized by a significant unmet medical need, while allowing us to leverage our leading HDL therapy capabilities to drive the development of this potentially revolutionary technology. We look forward to initiating the Phase I trial of NanoDisk and advancing other HDL-based assets, including CER-209 for NAFLD and NASH, in order to create value for patients, the medical community and other key stakeholders of CERENIS Therapeutics. Our enthusiasm about the fully enrolled TANGO trial continues, with results expected at the end of Q1, 2018."

Robert O. Ryan, Ph.D., Founder and Board Member of LYPRO, added: "We are extremely proud of accomplishments achieved by the LYPRO team. The product candidates that LYPRO has developed and associated with CERENIS’ proprietary HDL technology, could have a tremendous impact on the field of oncology, and we believe that CERENIS Therapeutics is the optimal company to lead future advancements of this groundbreaking technology. CERENIS Therapeutics holds the appropriate scientific, manufacturing, patent exclusivity, and clinical expertise to continue development of nanotechnology based delivery systems for therapies from laboratory bench to bedside."

Robert O. Ryan is a renowned expert in lipids, lipoproteins, lipid transport and metabolism. He is Professor and Chair of the Biochemistry and Molecular Biology Departments at the University of Nevada.

Michelle Stecklein Call, CEO of LYPRO Biosciences, added: "This agreement marks a transformational step for LYPRO Biosciences’ targeted HDL nanotechnology. CERENIS’ lead, drive and focus on HDL is a major competitive advantage to successfully take forward HDL-based targeted nanodelivery technologies to the market."

Combining LYPRO Biosciences’ NanoDisk technology with CERENIS’ HDL technology to build the first HDL particle delivery platform dedicated to the oncology market, including immuno-oncology and novel chemotherapeutic delivery technologies.

CERENIS acquires LYPRO Biosciences assets, including patent rights and in-depth pre-clinical data showing efficacy of lipid structures in encapsulating and delivering active drugs to tissues

LYPRO Biosciences is a privately-held therapeutic development company with a proprietary drug delivery nanotechnology that can increase the solubility and bioavailability of hydrophobic drugs and other therapeutic compounds as well as facilitates targeting to specific receptors. LYPRO’s technology, entitled "NanoDisk", is based on self-assembling, targetable, nanometer-scale bioparticles, incorporating active drugs into the stable and water-soluble NanoDisk.

The combination of the NanoDisk technology with CERENIS’ natural recombinant human apoA-I used in its HDL platform will result in the next generation of drug delivery platforms. This should allow for increased efficacy, while needing lower doses with reduced side effects compared to current drug delivery technology.

Targeting LYPRO NanoDisk to a specific cell surface receptor allows the delivery of a cell killing agent directly targeted to the diseased cell. Similar approaches are now being used for cancer treatment in the form of antibody-drug conjugates (ADC). However, these agents have a complex chemistry, limited drug to antibody stoichiometry and form an obstacle to drug release. Targeted NanoDisk may be considered as an ADC parallel technology unencumbered by ADC chemistries and patent estates.

A disruptive technology with high potential in targeted oncology and immuno-oncology

LYPRO’s most advanced technology, NanoDisk, combined with the CERENIS HDL, CER-001, targets a specific human cell HDL receptor, SR-B1. The SR-B1 and other HDL receptors (ABCA1) are scavenger receptors essential to cell homeostasis, proliferation and growth that are up-regulated in cancer cells. Therefore, these receptors serve as a potential gateway for the delivery of therapeutic agents when reconstituted HDL nanoparticles are used to transport agents to cancer cells and tumors.

Research underlying HDL used for delivering drugs to cancer cells and tumors as well as the role of the SR-B1 receptor as a potential gateway for the delivery of therapeutic agents was originally conducted by Professor Daniel Sparks, Ottawa Heart Institute Research Corporation, Ottawa, Canada, and has been published in a number of peer-reviewed publications (e.g. Zheng et al., Frontiers in Pharmacology 7:326, September 2016).

The Targeted NanoDisk technology developed by LYPRO Biosciences and allied with the CER-001, an engineered complex of recombinant human apoA-I, the major structural protein of HDL with phospholipids, holds the promise to target and selectively kill malignant cells while sparing healthy ones. A wide variety of drugs can be embedded in nanodisks which will target markers specific to cancer cells and bring these potent drugs to their intended site of action, with lowered systemic toxicity.

Using its existing technologies with LYPRO’s NanoDisk discoidal HDL, CERENIS is positioned to utilize HDL related particles to selectively target a wide variety of tissues. HDL nanoparticles are ideal drug carriers to target cancer cells thanks to their attractive biological features, having important advantages over other delivery systems.

HDL particles are natural carrier agents and more efficient than existing solutions

The ability to accommodate highly water insoluble constituents in their core regions enables HDL type nanoparticles to effectively transport hydrophobic drugs subsequent to systemic administration. While the utilization of reconstituted HDL as a carrier can be considered for the treatment of a number of diseases, the initial focus for CERENIS will be on HDL type drug delivery agents for cancer chemotherapy and immuno-oncology.

HDL nanotechnology presents several major advantages over drug delivery agents such as liposomes. First, lipoproteins, including synthetic lipoprotein formulations, tend to be much smaller (6-50 nm diameter) than liposomes. This feature may be a significant advantage as the smaller drug carrying nanoparticles could more effectively enter the tumor environment. Moreover, the HDL biological structure, as a naturally occurring particle, presents a superior safety profile as it is completely biodegradable.

HDL particles are adaptive with the ability to carry different types of molecules allowing for a different location and pace of release. From lipid-poor apoA-I to NanoDisk (discoidal HDL), HDL related particles will be able to target a wide variety of tissues.

A range of CERENIS’ drug delivery HDL particles present numerous advantageous characteristics, including:

1) Enhanced safety and efficacy yielding a solid, non-leaking preparation due to a structure stabilized by apolipoproteins, particularly apolipoprotein A-I (apoA-I).

2) Biocompatibility and safety of the carrier, shown by several pharmaceutical formulations, made up of essentially the same ingredients as natural HDL

3) Strong ability to target cancer cells via the expression of the SR-B1 receptors on the cells’ surface.

4) The receptor-mediated uptake of the payload, carried in the core of the HDL particle makes this strategy uniquely applicable, especially for cancer chemotherapy and antigen carrying immune-oncologic applications.

5) This wide range of applications is made possible as apoA-I is flexible to adapt from lipid-poor apoA-I, to discoidal particles allowing different types and quantities of drug payloads.

6) Finally, CERENIS owns the right to an exclusive validated manufacturing process to produce apoA-I, apoA-I peptides and HDL on an industrial scale, and the Company benefits from a strong patent barrier to entry, preventing the emergence of similar competitive technologies.

Phase I study, evaluating the technology’s safety in delivering active drugs to cancer tissues, to be launched by the end of 2019.

Acquiring the LYPRO Biosciences pre-clinical data supporting the proof of concept, CERENIS Therapeutics could launch, by the end of 2019, the first Phase I study to evaluate an HDL particle as a nano transporter of active drug for an oncologic indication. In the short term, CERENIS will set up a clear clinical strategy to select the most appropriate initial indication in oncology in order to demonstrate safety and efficacy of its new product candidate. The company also plans to advance its effort in the use of this technology to encapsulate tumor antigens to induce an immune response, possibly in combination with existing therapy (e.g. a checkpoint inhibitor) in the pursuit of immuno-oncology applications.

New strategic markets and value-creation prospects: Immuno-oncology is one of the most promising cancer treatment technology in a market valued at $100 billion by 2020.

Recognized by experts as one of the most promising fields in cancer treatment, immuno-oncology is an innovative approach to the treatment of cancers by leveraging the body’s own immune system.

The immunotherapy global market (antibodies, cancer vaccines, immune checkpoint inhibitors, immunomodulators) is valued at $100 billion by 2020. The prophylactic cancer vaccine market (exclusive of therapeutic cancer vaccines) is expected to reach $4 billion in valuation by 2019. Expectations and interest for therapeutic cancer vaccines have increased dramatically as a means to increase immuno-oncology drug response, duration and survival of poorly responding and non-responding cancer patients. There are few accurate estimates for the therapeutic cancer vaccine market as there are, to date, few successes and approvals. CERENIS’ new HDL-based targeted nanotherapeutics address a new potential market with a very large upside growth potential in the oncology field. It gives CERENIS a new strategic value for its markets related to its apoA-I/HDL technology and the development of a targeted nanotechnology platform.

On November 8, 2017 Syros Pharmaceuticals (NASDAQ: SYRS), a biopharmaceutical company pioneering the discovery and development of medicines to control the expression of disease-driving genes, reported financial results for the quarter ended September 30, 2017 and provided an update on recent accomplishments and upcoming events (Press release, Syros Pharmaceuticals, NOV 8, 2017, View Source [SID1234521766]).

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"Syros made significant progress in the third quarter, driving toward an initial clinical data readout at ASH (Free ASH Whitepaper) from our ongoing Phase 2 clinical trial of SY-1425 as well as adding a combination arm with SY-1425 and an anti-CD38 therapy to the trial, and continuing to execute efficiently on the dose escalation phase of our Phase 1 trial of SY-1365," said Nancy Simonian, M.D., Chief Executive Officer of Syros. "We presented key data on both programs, showing favorable PK and evidence of target engagement in patients from the clinical trial of SY-1425, as well as a significant correlation between the biomarker status of patients screened for the trial and differentiation of their cells treated ex vivo with SY-1425, supporting our platform’s ability to identify patients we believe may be most likely to respond to gene control therapies such as SY-1425. For SY-1365, we presented PK and PD data showing substantial anti-tumor activity in preclinical models of multiple cancers using a twice weekly dose consistent with the initial dosing regimen being used in the Phase 1 trial. We are at an exciting time in the company’s evolution, with multiple clinical data readouts for SY-1425 and SY-1365 expected between now and the end of 2018, a rich preclinical pipeline, and a leading gene control platform that we believe will continue to fuel our pipeline and fulfill our mission of improving patients’ lives."

Upcoming Milestones

Syros plans to report initial clinical data from the relapsed or refractory acute myeloid leukemia (AML) and higher-risk myelodysplastic syndrome (MDS) cohort, as well as the lower-risk transfusion-dependent MDS cohort, in its ongoing Phase 2 clinical trial of SY-1425, an oral first-in-class selective retinoic acid receptor alpha (RARα) agonist, at the 59th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition on Sunday, December 10, 2017. The presentation will include data on evidence of differentiation in patients’ bone marrow and initial assessments of clinical activity and safety of SY-1425 as a single agent. The Phase 2 trial is evaluating the safety and efficacy of SY-1425 as a single agent in four AML and MDS patient populations, as well as in combination with azacitidine in newly diagnosed AML patients who are not suitable candidates for standard chemotherapy. Syros recently amended the protocol of this trial to add a cohort evaluating the safety and efficacy of SY-1425 in combination with an anti-CD38 therapy in patients with relapsed or refractory AML or higher-risk MDS. The Company expects to begin enrolling patients in this cohort in early 2018. All patients enrolled or to be enrolled in the trial are prospectively selected using the Company’s RARA and IRF8 biomarkers.
Syros expects to present additional clinical data from the ongoing Phase 2 trial, including data assessing the safety and efficacy of SY-1425 in combination with azacitidine and with an anti-CD38 antibody, in 2018.
Syros plans to present new preclinical data at ASH (Free ASH Whitepaper) showing significant anti-tumor activity of SY-1365, a first-in-class selective cyclin-dependent kinase 7 (CDK7) inhibitor, in multiple leukemia and lymphoma cell lines, as well as in vivo models of AML. The Company also plans to present preclinical data at ASH (Free ASH Whitepaper) on its identification of a biomarker related to the mitochondrial apoptosis pathway that is predictive of sensitivity to SY-1365 in leukemia cell lines, as well as in vitro data showing synergy with the BCL2 inhibitor venetoclax.
Syros expects to report initial clinical data from its ongoing Phase 1 trial of SY-1365 in patients with advanced solid tumors in 2018.
Recent Platform and Pipeline Highlights

In October 2017, Syros presented preclinical PK and PD data on SY-1365 at the 2017 AACR (Free AACR Whitepaper)-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference. The data showed that SY-1365 has a prolonged PD effect and induces sustained tumor regressions in multiple preclinical models using intermittent dosing, supporting the twice weekly dosing regimen currently being used in the Phase 1 trial in patients with advanced solid tumors.
In October 2017, Syros announced a publication co-authored by two of its scientific founders, Nathanael S. Gray, Ph.D., and Richard A. Young, Ph.D., in the peer-reviewed scientific journal Cancer Discovery that highlighted CDK7 inhibition in combination with targeted therapies as a promising new approach for combatting drug resistance. In multiple in vitro and in vivo models of treatment-resistant cancers, CDK7 inhibition enhanced tumor cell killing and impeded the emergence of drug-resistant cell populations when combined with targeted therapies, including MEK, BRAF, EGFR and ALK inhibitors, compared to either a CDK7 inhibitor or the targeted therapy alone.
In October 2017, Syros’ drug discovery research in immuno-oncology was highlighted in an oral presentation at the American College of Surgeons 2017 Clinical Congress. As part of a research collaboration with the Lowy laboratory at the University of California San Diego Moores Cancer Center, Syros scientists identified alterations in regulatory regions of the genome in immune, tumor and stromal cells isolated from pancreatic cancer patient tumors. The goal of the Company’s immuno-oncology program is to discover and develop new drugs with the potential to reactivate the immune system to fight cancer.
In October 2017, Syros presented biomarker data from its ongoing Phase 2 clinical trial of SY-1425 at the European School of Haematology’s 4th International Conference on Acute Myeloid Leukemia "Molecular and Translational": Advances in Biology and Treatment. The data showed that the biomarker status of patients screened for the trial was predictive of myeloid cell differentiation in the patients’ blood samples treated ex vivo with SY-1425, supporting the potential clinical utility of the Company’s biomarkers for patient selection. Data also showed that SY-1425 robustly induced CD38 in an in vivo model of biomarker positive AML. Syros also announced that approximately 40% of the 201 evaluable patients screened for the clinical trial through August were biomarker-positive, including one-third of relapsed or refractory AML and higher-risk MDS patients.
In September 2017, Syros presented PK and PD data from its ongoing Phase 2 clinical trial of SY-1425 at the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) 2017 Congress. The data showed that the dosing regimen being used in the trial achieves blood levels sufficient to elicit a PD response with evidence of RARα target engagement. Data also showed no significant accumulation or reduction in drug exposure after two weeks of continuous dosing, demonstrating favorable PK properties compared to historical data with ATRA, a non-selective retinoic acid receptor agonist. Syros also presented the design of its ongoing Phase 1 trial for SY-1365 at ESMO (Free ESMO Whitepaper).
In August 2017, Syros announced that the U.S. Food and Drug Administration granted orphan drug designation to SY-1425 for the treatment of AML. Orphan drug designation may provide certain benefits, including a seven-year period of market exclusivity if the drug is approved, tax credits for qualified clinical trials and an exemption from FDA application fees.
Third Quarter 2017 Financial Results

Cash, cash equivalents and marketable securities as of September 30, 2017 were $81.9 million, compared with $83.6 million on December 31, 2016. The decrease in cash, cash equivalents and marketable securities is primarily due to cash used to fund operations during the nine-months ended September 30, 2017, partially offset by gross proceeds of approximately $35.0 million from Syros’ April 2017 private placement.

For the third quarter of 2017, Syros reported a net loss of $13.8 million, or $0.53 per share, compared to a net loss of $14.2 million, or $0.65 per share, for the same period in 2016. Stock-based compensation included in the net loss was $1.1 million for the third quarter of 2017, compared to $1.7 million for the same period in 2016.

Research and development (R&D) expenses were $10.4 million for the third quarter of 2017, as compared to $11.6 million for the same period in 2016. This decrease was primarily attributable to a $1.0 million milestone payment paid to TMRC Co., Ltd. in September 2016 upon the first dosing of a patient in the Phase 2 clinical trial of SY-1425 for which no comparable payment was made in 2017, a decrease in costs from third parties that conduct research and development and preclinical activities on the Company’s behalf that are primarily due to the completion of GLP toxicology studies for SY-1365 in 2016, and a decrease in stock-based compensation. These decreases were partially offset by increases in discovery expenses. Stock-based compensation included in R&D expenses was $0.4 million for the third quarter of 2017, compared to $1.2 million for the same period in 2016.
General and administrative (G&A) expenses were $3.6 million for the third quarter of 2017, as compared to $2.6 million for the same period in 2016. This increase was primarily attributable to an increase in employee-related costs, including salary, benefits and stock-based compensation. Stock-based compensation included in G&A expenses was $0.7 million for the third quarter of 2017, compared to $0.5 million for the same period in 2016.
Financial Guidance

Syros expects that its operating expenses for 2017 will be approximately $55.0 million. This amount includes approximately $5.0 million in non-cash expenses, primarily consisting of stock-based compensation and depreciation, resulting in an estimated cash burn of approximately $50.0 million for the year.

About Syros Pharmaceuticals

Syros Pharmaceuticals is pioneering the understanding of the non-coding region of the genome to advance a new wave of medicines that control expression of disease-driving genes. Syros has built a proprietary platform that is designed to systematically and efficiently analyze this unexploited region of DNA in human disease tissue to identify and drug novel targets linked to genomically defined patient populations. Because gene expression is fundamental to the function of all cells, Syros’ gene control platform has broad potential to create medicines that achieve profound and durable benefit across a range of diseases. Syros is currently focused on cancer and immune-mediated diseases and is advancing a growing pipeline of gene control medicines. Syros’ lead drug candidates are SY-1425, a selective RARα agonist in a Phase 2 clinical trial for genomically defined subsets of patients with acute myeloid leukemia and myelodysplastic syndrome, and SY-1365, a selective CDK7 inhibitor in a Phase 1 clinical trial for patients with advanced solid tumors, including transcriptionally dependent cancers such as triple negative breast, small cell lung and ovarian cancers. Led by a team with deep experience in drug discovery, development and commercialization, Syros is located in Cambridge, Mass.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, including without limitation statements regarding the reporting of initial clinical data from the ongoing Phase 2 clinical trial of SY-1425 at the ASH (Free ASH Whitepaper) Annual Meeting; the presentation of additional clinical data on SY-1425 and initial clinical data on SY-1365; the percentage of AML and MDS patients who have the RARA or IRF8 biomarker; the benefits of CDK7 inhibition; the ability to discover and develop drugs in the immuno-oncology field that can reactivate the immune system; anticipated operating expenses and cash burn for the year ended December 31, 2017; and the benefits of Syros’ gene control platform. The words ‘‘anticipate,’’ ‘‘believe,’’ ‘‘continue,’’ ‘‘could,’’ ‘‘estimate,’’ ‘‘expect,’’ ‘‘intend,’’ ‘‘may,’’ ‘‘plan,’’ ‘‘potential,’’ ‘‘predict,’’ ‘‘project,’’ ‘‘target,’’ ‘‘should,’’ ‘‘would,’’ and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Moreover, there can be no assurance that PK and PD data and ex vivo differentiation data generated to date in the ongoing Phase 2 clinical trial of SY-1425 are predictive of the ability of such trial to meet any of its endpoints. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including Syros’ ability to: advance the development of its programs, including SY-1425 and SY-1365, under the timelines it projects in current and future clinical trials; demonstrate in any current and future clinical trials the requisite safety, efficacy and combinability of its drug candidates; replicate scientific and non-clinical data in clinical trials; successfully develop a companion diagnostic test to identify patients with the RARA and IRF8 biomarkers; obtain and maintain patent protection for its drug candidates and the freedom to operate under third party intellectual property; obtain and maintain necessary regulatory approvals; identify, enter into and maintain collaboration agreements with third parties; manage competition; manage expenses; raise the substantial additional capital needed to achieve its business objectives; attract and retain qualified personnel; and successfully execute on its business strategies; risks described under the caption "Risk Factors" in Syros’ Quarterly Report on Form 10-Q for the quarter ended September 30, 2017, which is on file with the Securities and Exchange Commission; and risks described in other filings that Syros makes with the Securities and Exchange Commission in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and Syros expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise.

On November 8, 2017 Molecular Partners AG (MOLN.SW), a clinical-stage biopharmaceutical company developing a new class of drugs known as DARPin therapies, reported continued progress with its robust pipeline of therapeutic candidates in oncology and ophthalmology, as well as expansion of its early-stage immuno-oncology portfolio (Press release, Molecular Partners, NOV 8, 2017, View Source [SID1234521822]). Today’s R&D update in New York, entitled ”The DARPin Difference – Offering Patients a New Dimension of Protein Therapeutics,” will feature a series of presentations highlighting the scientific rationale and the potential clinical impact of the DARPin approach, as well as Molecular Partners’ continued forward integration and evolution towards becoming a fully integrated biopharmaceutical company.

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Today’s event for institutional investors, sell-side analysts, investment bankers, and business development professionals will take place in the Cosmopolitan Suite at the Four Seasons New York, 57 East 57th Street, from 12.00-2.30 pm EST. For those who are unable to attend in person, a live webcast and replay will be accessible.

”A growing body of scientific and clinical evidence suggests that our DARPin drug discovery platform is a powerful and practical engine for developing medicines that make a tangible difference in the lives of patients, physicians and society,” commented Patrick Amstutz, CEO of Molecular Partners. ”With a late-stage asset in ophthalmology, continued progress with two key oncology clinical development programs, and the emergence of MP0310, the first early-stage immuno-oncology compound originating from our I/O DARPin toolbox, we combine the scientific strength of our DARPin platform with a strong financial position.”

In addition to an overview of the Molecular Partners clinical and pre-clinical pipeline, the R&D update event will feature presentations by the following medical and scientific experts:

Prof. Angelo Vacca, MD, Chief of Internal Medicine, University of Bari Medical School, Bari, Italy: Multiple Myeloma (MM)
Kathryn A. Gold, MD, Associate Professor of Medicine, University of California San Diego Moores Cancer Center: Non-Small Cell Lung Cancer (NSCLC)
Richard Baird, PhD, Academic Consultant in Experimental Cancer Therapeutics, University of Cambridge, UK: HER2+ Breast Cancers
Baldo Scassellati Sforzolini, MD, PhD, MBA, Senior Vice President, Clinical Development, Allergan: abicipar, in wet age-related macular degeneration (wet AMD)
Attendees are invited to check in to today’s R&D update at 11:30 am EST. The presentations will begin at 12:15 pm, followed by a Q&A session. Lunch will be served. The live webcast and replay will be accessible here.

Financial Calendar

February 8, 2018 – Publication of Full-year Results 2017 (unaudited)
March 16, 2018 – Expected Publication of 2017 Annual Report
April 18, 2018 – Annual General Meeting
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On November 8, 2017 Supernus Pharmaceuticals, Inc. (NASDAQ:SUPN), a specialty pharmaceutical company focused on developing and commercializing products for the treatment of central nervous system diseases, reported that the Company’s management will present an overview and update for the Company, and host investor meetings at the following three conferences (Press release, Supernus, NOV 8, 2017, View Source [SID1234521813]):

Stifel 2017 Healthcare Conference
Date: Tuesday, November 14, 2017
Time: 11:45 a.m. EST
Place: Lotte New York Palace Hotel, New York

Jefferies 2017 London Healthcare Conference
Date: Thursday, November 16, 2017
Time: 4:40 p.m. GMT (11:40 a.m. EST)
Place: Waldorf Hilton, London, U.K.

Piper Jaffray 29th Annual Healthcare Conference
Date: Wednesday, November 29, 2017
Time: 8:00 a.m. EST
Place: Lotte New York Palace Hotel, New York

Investors interested in arranging a meeting with the Company’s management during these conferences should contact the conference coordinator.

A live webcast of the presentation can be accessed by visiting ‘Events & Presentations’ in the Investors Section on the Company’s website at www.supernus.com. An archived replay of these webcasts will be available for 60 days on the Company’s website after each conference.

On November 8, 2017 Keryx Biopharmaceuticals, Inc, (NASDAQ:KERX), a biopharmaceutical company focused on bringing innovative medicines to people with kidney disease, reported that it will webcast corporate presentations at the following investor conferences in November (Press release, Keryx Biopharmaceuticals, NOV 8, 2017, View Source/phoenix.zhtml?c=122201&" target="_blank" title="View Source/phoenix.zhtml?c=122201&" rel="nofollow">View Source;p=RssLanding&cat=news&id=2315586 [SID1234521798]):

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Stifel’s 2017 Healthcare Conference in New York City on Tuesday, November 14, 2017 at 3:30 p.m. ET
Jefferies’ 2017 Global Healthcare Conference in London, UK, on Thursday, November 16, 2017 at 8:40 a.m. GMT (3:40 a.m. ET)
A fireside chat at the 29th Annual Piper Jaffray Healthcare Conference in New York City on Tuesday, November 28, 2017 at 2:00 p.m. ET
Live audio webcasts of the presentations will be accessible from Keryx Biopharmaceuticals’ website at View Source within the Investor Relations section under "webcasts and presentations." An archived version of the webcast will be available for at least 15 days following the conclusion of the live presentations.