On September 10, 2020 Aldeyra Therapeutics, Inc. (Nasdaq: ALDX) (Aldeyra) reported that senior management will be presenting and hosting one-on-one meetings at the following investor conferences (Press release, Aldeyra Therapeutics, SEP 10, 2020, View Source [SID1234564972]):

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H.C. Wainwright 22nd Annual Global Investment Conference
Presentation Date: Monday, September 14, 2020
Time: 3:30 p.m. ET
2020 Cantor Global Virtual Healthcare Conference
Presentation Date: Wednesday, September 16, 2020 (Fireside Chat)
Time: 2:40 p.m. ET
A live webcast of the presentations will be available on the investor relations page of the company’s corporate website at View Source After the live webcast, the events will remain archived on the Aldeyra Therapeutics website for 90 days.

On September 10, 2020 ADC Therapeutics SA (NYSE: ADCT), a late clinical-stage oncology-focused biotechnology company pioneering the development and commercialization of highly potent and targeted antibody drug conjugates (ADCs) for patients with hematological malignancies and solid tumors, reported that preclinical data related to camidanlumab tesirine (Cami, formerly ADCT-301) has been published in the Journal for ImmunoTherapy of Cancer, the online journal of the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper), in a paper titled, "CD25-targeted antibody-drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity (Press release, ADC Therapeutics, SEP 10, 2020, View Source [SID1234564971])."

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The study evaluated the antitumor activity of a pyrrolobenzodiazepine (PBD) dimer-based, CD25-targeted ADC, either alone or in combination with a checkpoint inhibitor, in CD25-negative syngeneic colon cancer models that exhibit tumor infiltration of CD25-expressing regulatory T cells (Tregs). Data demonstrated that single low doses of the CD25-targeted ADC resulted in potent and durable antitumor activity against established CD25-negative solid tumors with infiltrating Tregs, both as a monotherapy and in combination with an anti-PD1 checkpoint inhibitor.

Patrick van Berkel, Ph.D., Senior Vice President of Research and Development at ADC Therapeutics, said, "CD25 is expressed on Tregs that infiltrate the local tumor environment. We were pleased to see that our CD25-targeted ADC depleted CD25-expressing Tregs and not only showed strong anti-tumor activity as a monotherapy in preclinical models, but it also enhanced the activity of anti-PD1 treatment in these models. This study provides proof of concept for a new application of ADCs as immunotherapeutic agents and supports the continued evaluation of Cami in our ongoing Phase 1b clinical trial in patients with selected advanced solid tumors. We look forward to advancing the exploration of Cami as a novel immune-oncology approach for the treatment of solid tumors."

For information about the company’s Phase 1b clinical trial of Cami in solid tumors, visit www.clinicaltrials.gov (identifier NCT03621982).

About Camidanlumab Tesirine (Cami)

Camidanlumab tesirine (Cami, formerly ADCT-301) is an antibody drug conjugate (ADC) comprised of a monoclonal antibody that binds to CD25 (HuMax-TAC, licensed from Genmab A/S), conjugated to the pyrrolobenzodiazepine (PBD) dimer payload, tesirine. Once bound to a CD25-expressing cell, ADCT-301 is internalized into the cell where enzymes release the PBD-based warhead killing the cell. This applies to CD25-expressing tumor cells, and also to CD25-expressing Tregs. The intra-tumoral release of its PBD warhead may also cause bystander killing of neighboring tumor cells and PBDs have also been shown to induce immunogenic cell death. All these properties of Cami may enhance immune-mediated anti-tumor activity. Cami is being evaluated in a pivotal Phase 2 clinical trial in patients with relapsed or refractory Hodgkin lymphoma (HL), as well as in a Phase 1a/1b clinical trial in patients with relapsed or refractory HL and non-Hodgkin lymphoma and a Phase 1b clinical trial in solid tumors.

On September 10, 2020 Gossamer Bio, Inc. (Nasdaq: GOSS), a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology, reported its participation in two upcoming investor conferences. Sheila Gujrathi, M.D., Chief Executive Officer and Co-Founder, and Bryan Giraudo, Chief Financial Officer, will present at the H.C. Wainwright 22nd Annual Global Investment Conference on Monday, September 14 at 5:00 p.m. ET and at the Cantor Fitzgerald Virtual Global Healthcare Conference on Thursday, September 17 at 2:00 p.m. ET (Press release, Gossamer Bio, SEP 10, 2020, View Source [SID1234564970]).

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Live webcasts of both presentations will be available on the "Events and Presentations" page in the "Investors" section of the company’s website at View Source Replays of each webcast will be archived on the company’s website for 90 days following the presentation.

On September 10, 2020 Exicure, Inc. (Nasdaq: XCUR), a pioneer in gene regulatory and immunotherapeutic drugs utilizing spherical nucleic acid (SNA) constructs, reported presentations at the following conferences during the month of September (Press release, Exicure, SEP 10, 2020, View Source [SID1234564969]):

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TIDES: Oligonucleotide & Peptide Therapeutics
Panel discussion: The impact of technological advances in the TIDES Space
Presented by: CEO David Giljohann
Tuesday, September 15, 2020

Panel Discussion: Streamlining the transition from discovery to manufacturing
Presented by: Vice President of Translational Research Weston Daniel
Tuesday, September 15, 2020
H.C. Wainwright 22nd Annual Global Investment Conference
Corporate update
Presented by: CEO David Giljohann
Tuesday, September 15, 2020 at 1:00pm ET
Replays of the H.C. Wainwright webcast will be available on Exicure’s website for 90 days following the webcast.

On September 10, 2020 Pfizer Inc. (NYSE:PFE) reported that more than 50 abstracts representing data from nine approved and investigational Pfizer medicines, including several biomarker-driven and immuno-therapies, will be presented at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Virtual Congress 2020 being held from September 19-21, 2020 (Press release, Pfizer, SEP 10, 2020, View Source [SID1234564968]). Data to be presented include findings from the Phase 3 CROWN study of LORBRENA (lorlatinib)* in first-line ALK-positive non-small cell lung cancer (NSCLC), building on Pfizer’s extensive heritage in precision medicine research.

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In addition to the CROWN study, several biomarker analyses that provide further insights on Pfizer medicines across a range of cancers will be presented, including BAVENCIO (avelumab), BRAFTOVI (encorafenib) + MEKTOVI (binimetinib), and IBRANCE (palbociclib). BAVENCIO is being developed and commercialized in collaboration with Merck KGaA, Darmstadt, Germany.

"Meaningful innovation in cancer care requires building upon our understanding of tumor biology, leveraging cutting-edge research, and applying the knowledge we gain into new treatments that address and prevent resistance," said Chris Boshoff, M.D., Ph.D., Chief Development Officer, Oncology, Pfizer Global Product Development. "We are proud to share the latest insights on our cancer medicines at ESMO (Free ESMO Whitepaper) this year, including data from the CROWN trial examining the first-line use of our third-generation biomarker-driven therapy in ALK-positive non-small cell lung cancer."

Pfizer will also continue its commitment to help non-scientists understand the latest findings with the development of abstract plain language summaries (APLS) for company-sponsored research being presented at ESMO (Free ESMO Whitepaper), which are written in non-technical language. Those interested in learning more can visit www.Pfizer.com/apls to access the summaries starting September 18.

Key presentations featuring Pfizer medicines at ESMO (Free ESMO Whitepaper) include:

Pfizer-Sponsored Studies

Proffered Paper (Presentation LBA2)

Saturday, September 19, 2020

Lorlatinib vs Crizotinib in the First-line Treatment of Patients with Advanced ALK-Positive Non-Small Cell Lung Cancer (NSCLC): Results of the Phase 3 CROWN Study

Solomon B.

Proffered Paper (Presentation 699O)

Saturday, September 19, 2020

Avelumab First-line (1L) Maintenance + Best Supportive Care (BSC) vs BSC Alone for Advanced Urothelial Carcinoma (UC): Association between Clinical Outcomes and Exploratory Biomarkers

Sridhar S.

Proffered Paper (Presentation 910O)

Saturday, September 19, 2020

Primary Results of the Phase III JAVELIN Head & Neck 100 Trial: Avelumab Plus Chemoradiotherapy (CRT) Followed by Avelumab Maintenance vs CRT in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck (LA SCCHN)

Cohen E.

Mini Oral (Presentation 704MO)

Friday, September 18, 2020

Avelumab First-line (1L) Maintenance + Best Supportive Care (BSC) vs BSC Alone with 1L Chemotherapy (CTx) for Advanced Urothelial Carcinoma (UC): Subgroup Analyses from JAVELIN Bladder 100

Grivas P.

Investigator-Sponsored Studies and Clinical Research Collaborations

Proffered Paper (Presentation LBA12)

Sunday, September 20, 2020

PALLAS: A Randomized Phase III Trial of Adjuvant Palbociclib with Endocrine Therapy Versus Endocrine Therapy Alone for HR+/HER2- Early Breast Cancer

Mayer E.

Proffered Paper (Presentation LBA45)

Saturday, September 19, 2020

First Report of Efficacy and Safety from the Phase II Study SECOMBIT (SEquential COMBo Immuno and Targeted Therapy Study)

Ascierto P.

Mini Oral (Presentation LBA27)

Friday, September 18, 2020

Phase II Multicenter, Randomized Study to Evaluate Efficacy and Safety of Avelumab with Gemcitabine/Carboplatin (CG) vs CG Alone in Patients with Unresectable or Metastatic Urothelial Carcinoma (mUC) Who Are Ineligible to Receive Cisplatin-based Therapy

Pérez Valderrama B.

Presentations will be available to registered attendees during the Congress at www.ESMO.org. A complete list of Pfizer-sponsored abstracts will be available at View Source

Merck KGaA, Darmstadt, Germany and Pfizer have a global strategic alliance to jointly develop and commercialize BAVENCIO.

*LORBRENA (lorlatinib) is available in the European Union under the brand name LORVIQUA.

Prescribing Information for Pfizer Medicines

Please see full US Prescribing Information and Medication Guide for BAVENCIO (avelumab) available at www.Bavencio.com.
Please see full Prescribing Information for BRAFTOVI (encorafenib) + MEKTOVI(binimetinib) available at www.BraftoviMektovi.com.
Please see full Prescribing Information for IBRANCE (palbociclib) at www.Ibrance.com.
Please see full Prescribing Information for LORBRENA (lorlatinib) at www.Lorbrena.com.
Please see full Prescribing Information for XALKORI (crizotinib) at www.Xalkori.com.