On November 1, 2018 ImmunoGen, Inc., (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, reported that abstracts highlighting two of the Company’s experimental ADC therapies, IMGN779 and IMGN632, have been accepted for presentations at the upcoming American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting to be held December 1-4 in San Diego, California (Press release, ImmunoGen, NOV 1, 2018, View Source [SID1234530514]).

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Both IMGN779 and IMGN632 use ImmunoGen’s novel indolino-benzodiazepine payloads called IGNs, which alkylate DNA without crosslinking. IGNs have been designed to have high potency against acute myeloid leukemia (AML) blasts, while demonstrating less toxicity to normal marrow progenitors than other DNA-targeting payloads.1 IMGN779 is a next-generation anti-CD33 ADC for the treatment of AML, currently in Phase 1 testing. IMGN632 is a CD123-targeting ADC for hematological malignancies, including AML and blastic plasmacytoid dendritic cell neoplasm (BPDCN), and is also in Phase 1 testing.

In an oral presentation, safety and anti-leukemia activity findings from the ongoing dose escalation study of IMGN779 in patients with relapsed or refractory AML will be reported. In a separate oral presentation, initial safety and anti-leukemia activity findings from the dose escalation stage of the first-in-human trial of IMGN632 will be reported. Preclinical data related to IMGN632 will also be presented in poster sessions.

ORAL PRESENTATIONS

Title (Abstract #26): "Maturing Clinical Profile of IMGN779, a Next-Generation CD33-Targeting Antibody-Drug Conjugate, in Patients with Relapsed or Refractory Acute Myeloid Leukemia"
Oral session 613: Saturday, December 1, 2018, 7:45am PST
Title (Abstract #27): "A Phase I, First-in-Human Study Evaluating the Safety and Preliminary Antileukemia Activity of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate, in Patients with Relapsed/Refractory Acute Myeloid Leukemia and Other CD123-Positive Hematologic Malignancies"
Oral session 613: Saturday, December 1, 2018, 8:00am PST.
POSTER SESSIONS

Title (Abstract #2647): "Synergistic anti-leukemia activity of PARP inhibition combined with IMGN632, an anti-CD123 antibody-drug conjugate in acute myeloid leukemia models"
Poster session 604: Sunday, December 2, 2018, 6:00-8:00pm PST
Title (Abstract #3956): "Pre-clinical efficacy of CD123-targeting antibody-drug conjugate IMGN632 in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) models"
Poster session 605: Monday, December 3, 2018, 6:00-8:00pm PST
Additional information can be found at www.hematology.org, including abstracts.

ABOUT IGNs

Indolino-benzodiazepine cancer-killing agents, or IGNs, are a new class of cancer-killing agent developed by ImmunoGen for use in ADCs. These ultra-potent, DNA-acting IGNs alkylate DNA without crosslinking, which preclinically has resulted in potent anti-leukemia activity with relative sparing of normal hematopoietic progenitor cells.

ABOUT IMGN779

IMGN779 is a novel ADC that combines a high-affinity, humanized anti-CD33 antibody, a cleavable disulfide linker, and one of ImmunoGen’s novel indolino-benzodiazepine payloads, called IGNs, which alkylate DNA without crosslinking, resulting in potent preclinical anti-leukemia activity with relative sparing of normal hematopoietic progenitor cells. IMGN779 is in Phase 1 clinical testing for the treatment of AML.

ABOUT IMGN632

IMGN632 is a novel, anti-CD123 antibody-drug conjugate that is a potential treatment for AML, BPDCN, and other CD123-positive malignancies. IMGN632 uses a novel humanized anti-CD123 antibody coupled via a peptide linker to a unique DNA-alkylating IGN payload. In preclinical models, IMGN632 has exhibited potent antitumor activity with a wide therapeutic index in AML, BPDCN, and acute lymphoblastic leukemia (ALL). IMGN632 is in Phase 1 clinical testing for the treatment of AML and BPDCN.