Agenus to Present BOT+BAL Long-Term Survival Data and Translational Research With agenT-797 in Colorectal Cancer at SITC 2026

On October 2, 2026 Agenus Inc. (Nasdaq: AGEN), a leader in immuno-oncology innovation, reported that two posters highlighting research on botensilimab (BOT), an Fc-enhanced multifunctional anti-CTLA-4 antibody, in combination with balstilimab (BAL), an anti-PD-1 antibody, have been accepted for presentation at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 2026 Annual Meeting, taking place November 4-8, 2026, in Phoenix, Arizona.

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The clinical poster will review the features of long-term survivors of refractory microsatellite-stable (MSS) metastatic colorectal cancer (mCRC) who have been treated with BOT+BAL. A second poster will highlight translational research of BOT+BAL in combination with MiNK Therapeutics’ agenT-797 (iNKT cell therapy) with in a preclinical model of colorectal cancer liver metastases.

Presentation Details

Abstract Title: Clinical features of long-term survivors treated with next-generation anti-CTLA-4 (botensilimab) plus anti-PD-1 (balstilimab) in refractory microsatellite-stable metastatic colorectal cancer
Presenter: Thomas U. Marron, MD, PhD; Mount Sinai, Tisch Cancer Center, New York, NY, USA
Date: Saturday, November 7, 2026
Time: 10:00 a.m. – 2:00 p.m. and 6:00-8:10 p.m. MST
Location: North Building, Lower Level, Exhibition Halls 4–5–6
Poster No.: 472

Abstract Title: AgenT-797, an allogeneic iNKT cell therapy, enables tumor-cell killing in a human organoid model of immune checkpoint inhibitor–refractory colorectal cancer liver metastases
Presenter: Shanmugarajan Krishnan, Ph.D., M.S., B.S.; Agenus Inc., Lexington, MA
Date: Saturday, November 7, 2026
Time: 10:00 a.m. to 2:00 p.m. and 6:00 to 8:10 p.m. MST
Location: North Building, Lower Level, Exhibition Halls 4–5–6
Poster No.: 270

(Press release, Agenus, OCT 2, 2026, View Source [SID1234671243])