On November 4, 2026 Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation, reported that preliminary clinical data from the Phase 1 study of ARV-393 (zaloblideg) in patients with relapsed/refractory non-Hodgkin lymphoma (NHL) will be presented at the 2026 American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting, taking place December 12- 15, 2026, in New Orleans, Louisiana.
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ARV-393 (zaloblideg) is Arvinas’ investigational, orally bioavailable PROteolysis TArgeting Chimera (PROTAC) designed to specifically target and degrade the B-cell lymphoma 6 (BCL6) protein. BCL6 is a master regulator of germinal center B-cell development, an established oncogenic driver in multiple NHLs and more recently implicated in nodal T-follicular helper cell lymphoma of angioimmunoblastic type (nTFHL-AI, formerly AITL).
The presentation details are as follows:
Presentation Title: ARV-393, an oral PROTAC BCL6 degrader, in patients with non-Hodgkin lymphoma: Preliminary results from a phase 1 study
Presentation Type: Poster
Session Number: 627
Session Title: Aggressive Lymphomas: Targeted and Pharmacologic Therapies: Poster III
Session Location: MCCNO – Hall F
Publication Number: 5409
Date: Monday, December 14
Session Time: 6:00-8:00 PM CT
The full abstract can be accessed via the ASH (Free ASH Whitepaper) online program.
About ARV-393 (zaloblideg)
Zaloblideg is an investigational, orally bioavailable PROTAC designed to specifically target and degrade B-cell lymphoma 6 protein (BCL6), a transcriptional repressor and major driver of B-cell lymphomas. During B-cell development, tightly controlled BCL6 protein expression regulates >600 genes to facilitate rapid B-cell proliferation and tolerance of somatic hypermutation and gene recombination for antibody generation. Deregulated BCL6 expression is common in B-cell lymphoma and promotes cancer cell survival, proliferation, and genomic instability. PROTAC-mediated degradation has the potential to address the historically undruggable nature of BCL6. ARV-393 (zaloblideg) is currently being evaluated in a Phase 1 clinical trial as a monotherapy in patients with relapsed/refractory non-Hodgkin lymphoma and in in combination with glofitamab as a chemotherapy-free combination approach in patients with DLBCL.
(Press release, Arvinas, NOV 4, 2026, View Source [SID1234674200])