On November 3, 2026 Avacta Therapeutics (AIM: AVCT, "the Company", "Avacta"), a life sciences company developing innovative, targeted oncology drugs, reported it will present AVA6207, its Next-Generation pre|CISION dual payload peptide-drug conjugate (PDC), in a poster at the 38th EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) Symposium on Molecular Targets and Cancer Therapeutics, taking place in Barcelona, Spain, from November 18-20.
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AVA6207 uses the Company’s pre|CISION PDC technology to deliver two synergistic payloads directly to tumor cells in a single molecule, combining two complementary mechanisms to combat highly resistant cancers. This dual payload molecule functions by inhibiting topoisomerase I (TOP1i), inducing severe DNA damage, while simultaneously inhibiting Ataxia Telangiectasia and Rad3-related (ATR) kinase through an ATR inhibitor (ATRi), thus blocking the DNA damage response to prevent cancer cells from repairing TOP1i-induced damage. Combining these two payloads into one pre|CISION PDC that delivers them directly to the tumor has tremendous potential to improve outcomes in TOP1i-resistant cancers, a growing area of unmet need in oncology.
Details of the poster presentation
Title: AVA6207 is a novel pre|CISION technology compound delivering complementary TOP1i and ATRi payloads to the tumor microenvironment following FAP cleavage
Authors: Victoria Juskaite, Tom Clough, Ellen Watts, et al. and David Jones
Session Title: DNA Repair Modulation (e.g. PARP, CHK, ATR, ATM)
Session Date and Time: Thursday, November 19, 09:00-17:30
Location: Exhibition Hall, Poster Area
Abstract Number: 161
(Press release, Avacta Life Sciences, NOV 3, 2026, View Source [SID1234674119])