On April 3, 2017 Bicycle Therapeutics, a biotechnology company pioneering a new class of therapeutics based on its proprietary bicyclic peptide (Bicycle) product platform, reported that the company will present preclinical data supporting the ongoing development of its lead molecule, BT1718 (Press release, Bicycle Therapeutics, APR 3, 2017, View Source [SID1234518437]). This program is the first example of its Bicycle Drug Conjugate technology, which allows toxic payloads to be targeted to tumour types of high unmet medical need. BT1718 targets Type 1 Matrix Metalloproteinase (MT1-MTP), which is highly expressed in many solid tumours, including triple negative breast cancer and non-small cell lung cancer. The data will be presented in three poster presentations at the Annual Meeting of the American Association for Cancer Research (AACR) (Free AACR Whitepaper), being held in Washington, DC from April 1 through April 5, 2017.

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Details for the poster presentations at the 2017 AACR (Free AACR Whitepaper) Annual Meeting are as follows:
Title: Development of BT1718, a novel Bicycle Drug Conjugate for the treatment of lung cancer
Session Title: Novel Molecular Targets 1
Abstract #: 1167/12
Date & Time: April 3, 2017, 8:00 a.m. – 12:00 p.m. EST

Title: Bicyclic peptides for PET imaging of MT1-MMP expressing tumors
Session Title: Clinical Laboratory and Imagine Correlates
Abstract #: 3719/4
Date & Time: April 4, 2017, 8:00 a.m. – 12:00 p.m. EST

Title: BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumors: Design of bicyclic peptide and linker selection
Session Title: Novel Drug Delivery Technology
Abstract #: 5144 / 16
Date & Time: April 5, 2017, 8:00 a.m. – 12:00 p.m. EST