On April 2, 2017 Precision-Biologics Inc. reported an abstract reporting data on the company’s neo-antigen program has been accepted for an oral presentation at the upcoming 110th Annual Meeting of the American Association of Clinical Research (AACR) (Free AACR Whitepaper) in Washington D.C., April 1-5, 2017 (Press release, Precision Biologics, APR 2, 2017, View Source [SID1234518432]). Schedule your 30 min Free 1stOncology Demo! "Precision Biologics continues to make progress with our preclinical and clinical programs," said Philip M. Arlen, President and CEO of Precision Biologics. "As this study demonstrates, our novel, humanized IgG1 monoclonal antibody, NEO-201, specifically targets a neoantigen expressed on a broad range of solid tumors. Tumor cell killing, antibody-dependent, cell-mediated cytotoxicity (ADCC), was significantly enhanced when NEO-201 was combined with an allogenic source of natural killer cells provided by NantKwest (Nasdaq:NK)."
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Patrick Soon-Shiong, MD, Chairman and CEO of NantCell added, "These results highlight the potential to synergistically improve the response of antibody therapy when used in combination with NantKwest’s off-the-shelf natural killer cells." Dr. Soon-Shiong continued," Neoantigen targeting is an attractive, emerging therapeutic approach to next generation cancer care and NEO-201, with specificity to tumor tissues and not normal tissues, offers the potential to further improve response rates and look to transitioning this NEO-201/NK cell combination into human clinical trials targeting ovarian, GI and other cancer types as quickly as possible."
Presentation Summary
Preclinical characterization of a novel monoclonal antibody targeting a neo-antigen expressed in ovarian and GI malignancies
Abstract #3025,View Source!/4292/presentation/5981
Presenter: Kristen Zeligs, MD Walter Reed National Military Medical Center, Bethesda, MD
Monday, April 3, 2017, 4:05-4:20PM, Ballroom A-B
This oral presentation will present preclinical data demonstrating the potential benefit of targeting the NEO-201 neoantigen in both cancer cell lines as well as patient’s tumors. NEO-201 monoclonal antibody was shown to mediate ADCC activity, which was further enhanced when used with allogenic natural killer cells in tumor cell lines expressing the NEO-201 neoantigen. The NEO-201 antigen is expressed on numerous solid tumors with minimal expression on healthy tissue. The company plans to move this program into human clinical trials in the near future.
In October 2015, NantCell Inc., a subsidiary of NantWorks, LLC, acquired a majority stake in Precision Biologics with a $50 million investment. NantCell made the investment to further its efforts to activate the human immune system to treat the biology of cancer and avoid the toxic effects of standard chemotherapy. With Precision Biologics proprietary library of cancer vaccines, NantCell is working on developing compounds that could change the way cancer is detected and treated.