On May 8, 2026 Boundless Bio (Nasdaq: BOLD), a clinical-stage oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to patients with previously intractable oncogene amplified cancers, reported financial results and business highlights for the fiscal quarter ended March 31, 2026.

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"We are encouraged by the progress of the KOMODO-1 trial," said Zachary Hornby, President and Chief Executive Officer of Boundless Bio. "We continue to expand the body of evidence supporting BBI-940’s kinesin degradation mechanism, with our recent AACR (Free AACR Whitepaper) poster demonstrating anti-tumor activity and tumor regression across multiple ecDNA+ cancer models. These findings further strengthen our confidence in the therapeutic potential of BBI-940 as we advance the program through a first-in-human clinical trial."

Business Highlights and Upcoming Milestones

BBI-940 Novel Kinesin Degrader Clinical Program

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Enrollment is ongoing in KOMODO-1 (Kinesin Oral Molecular Degrader for Oncology-1), a first-in-human clinical trial of BBI-940 in patients with estrogen receptor positive and human epidermal growth factor receptor 2 negative (ER+/HER2-) breast cancer who have progressed following treatment with a cyclin-dependent kinase 4 and/or 6 (CDK4/6) inhibitor plus endocrine therapy, as well as patients with triple-negative breast cancer luminal androgen receptor subtype (TNBC-LAR).
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Initial safety and efficacy clinical proof-of-concept data are expected within the Company’s existing cash runway timeline.

Validating Kinesin Degradation Data Presented at 2026 AACR (Free AACR Whitepaper) Annual Meeting

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In vitro and in vivo study data were presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026, which demonstrated that genetic depletion and pharmacologic degradation of a novel kinesin (Kinesin) cause ecDNA mis-segregation, ecDNA reduction, and reduced viability of ecDNA positive (ecDNA+) cancer cells.
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Further, selective degradation of Kinesin in a panel of tumor cell lines demonstrated sensitivity across multiple tumor types, including 32% of breast cancer cell lines, including those positive for ecDNA and FGFR1 gain. This molecularly defined subgroup for Kinesin degradation sensitivity was further validated in vivo with demonstrated monotherapy tumor regressions in an ecDNA+ TNBC-LAR model, and significant antitumor activity as monotherapy and in combination with fulvestrant in an ecDNA+/FGFR1+ ER+ breast cancer model.

First Quarter 2026 Financial Results

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Cash Position: Cash, cash equivalents, and short-term investments totaled $92.8 million as of March 31, 2026. The Company expects its cash to fund operations into the second half of 2028.
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Research and Development (R&D) Expenses: R&D expenses were $9.7 million for the first quarter of 2026 compared to $12.1 million for the same period in 2025.
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General and Administrative (G&A) Expenses: G&A expenses were $4.7 million for the first quarter of 2026 compared to $5.2 million for the same period in 2025.
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Net Loss: Net loss totaled $13.6 million for the first quarter of 2026 compared to $15.8 million for the same period in 2025.

(Press release, Boundless Bio, MAY 8, 2026, View Source [SID1234665384])