On July 20, 2026 Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CANF), a clinical-stage biotechnology company developing a pipeline of proprietary small molecule drugs targeting oncological and inflammatory diseases, reported that an abstract highlighting positive results from its Phase 2a study of Namodenoson in patients with advanced pancreatic ductal adenocarcinoma (PDAC), has been accepted for poster presentation at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress 2026.
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The accepted abstract, entitled "Durable Disease Stabilization with Namodenoson in Advanced Pancreatic Adenocarcinoma: Results from a Phase 2a Study," will be presented as a poster during the ESMO (Free ESMO Whitepaper) Congress, one of the world’s premier scientific meetings in oncology.
The Phase 2a study evaluated oral Namodenoson in patients with advanced pancreatic cancer who had progressed following prior standard therapies. As previously announced, the study successfully achieved its primary safety endpoint and demonstrated encouraging survival outcomes together with durable disease stabilization in this difficult-to-treat patient population.
"We are pleased that our abstract has been selected for presentation at ESMO (Free ESMO Whitepaper), one of the most prestigious international oncology conferences," said Pnina Fishman, Ph.D., Chairperson and Chief Scientific Officer of Can-Fite BioPharma. "Acceptance by ESMO (Free ESMO Whitepaper) provides important scientific recognition of our pancreatic cancer program and offers an opportunity to present our clinical findings to the global oncology community. We believe these data further support the continued development of Namodenoson for patients with advanced pancreatic cancer."
Namodenoson is a highly selective A3 adenosine receptor agonist with a unique mechanism of action that induces apoptosis of cancer cells while exhibiting an excellent safety profile. The drug has demonstrated anti-tumor activity across multiple preclinical models, including pancreatic cancer, and is also being developed for hepatocellular carcinoma and MASH.
Can-Fite is currently planning the next stage of clinical development for Namodenoson in pancreatic cancer, with a Phase 2b study designed to evaluate Namodenoson in combination with chemotherapy based on encouraging clinical findings and supportive preclinical evidence demonstrating synergistic anti-tumor activity.
Additional details regarding the poster presentation, including presentation date, session information, and poster number, will be announced when they become available.
About Pancreatic Ductal Adenocarcinoma (PDAC)
Pancreatic ductal adenocarcinoma is among the most aggressive malignancies and remains a leading cause of cancer-related mortality worldwide. Patients with advanced disease who progress following standard therapies have limited treatment options and continue to face poor clinical outcomes, underscoring the need for novel therapeutic approaches.
About Namodenoson
Namodenoson is a small orally bioavailable drug that binds with high affinity and selectivity to the A3 adenosine receptor (A3AR). Namodenoson is currently being evaluated in a pivotal Phase 3 trial for advanced liver cancer, concluded successfully a Phase 2a study in pancreatic cancer and is enrolling patients in a Phase 2b trial for the treatment of Metabolic Dysfunction-associated Steatohepatitis (MASH). A3AR is highly expressed in diseased cells whereas low expression is found in normal cells. This differential expression may be one of the important factors that accounts for the excellent safety profile of the drug.
(Press release, Can-Fite BioPharma, JUL 20, 2026, View Source [SID1234669312])