On March 21, 2023 Carina Biotech (Carina), a cell therapy immuno-oncology company, reported four poster presentations from preclinical studies of its LGR5-targeting CAR-T platform in colorectal cancer at the 2023 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting that will take place in Orlando, Florida on April 14-19 (Press release, Carina Biotech, MAR 21, 2023, View Source [SID1234629094]).
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"We are looking forward to sharing preclinical data related to our LRG-5 targeted CAR-T platform in colorectal cancer at the upcoming 2023 AACR (Free AACR Whitepaper) meeting. The data expand upon the preclinical evidence supporting our LGR5 CAR-T cell candidate CNA3013 and the planned Phase 1/2a clinical trial in patients with advanced colorectal cancer patients. This follows the greenlight for our CNA3103 Investigational New Drug (IND) application by the US Food and Drug Administration (FDA) in January 2023," stated Deborah Rathjen, PhD, Carina’s Chief Executive Officer.
Poster Presentation Details
Title: Development of a flow cytometry-based assay for measuring specific CAR expression on LGR5-targeting CAR-T cells
Lead Author: Timona Tyllis, Chemokine Biology Laboratory, Department of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia
Session Category: Clinical Research Excluding Trials
Session Title: Adoptive Cell Therapy 2
Session Date and Time: Monday Apr 17, 2023 from 1:30 PM ET – 5:00 PM ET
Location: Poster Section 37
Poster Board Number: 19
Published Abstract Number: 3199
Title: Development and in vitro validation of an LGR-5 targeting CAR-T against colorectal cancer
Lead Author: Veronika Bandara, Centre for Cancer Biology, an Alliance between University of South Australia and SA Pathology, Adelaide, South Australia
Session Category: Immunology
Session Title: CAR T-cell Therapy 2
Session Date and Time: Tuesday Apr 18, 2023 from 9:00 AM ET – 12:30 PM ET
Location: Poster Section 23
Poster Board Number: 4
Published Abstract Number: 4085
Title: In vivo efficacy of LGR5-targeting CAR-T cell therapies developed for the treatment of colorectal cancer
Lead Author: Dylan McPeake, Chemokine Biology Laboratory, Department of Molecular and Biomedical Science, The University of Adelaide, Adelaide, South Australia
Session Category: Immunology
Session Title: CAR T-cell Therapy 2
Session Date and Time: Tuesday Apr 18, 2023 from 9:00 AM ET – 12:30 PM ET
Location: Poster Section 23
Poster Board Number: 2
Published Abstract Number: 4083
Title: Assessing LGR5 expression levels on colorectal cancer tissue samples for use in a LGR5-targeting CAR-T cell therapy clinical trial
Lead Author: Emma J. Thompson, Centre for Cancer Biology, an Alliance between University of South Australia and SA Pathology, Adelaide, South Australia
Session Category: Clinical Research Excluding Trials
Session Title: Diagnostic and Prognostic Biomarkers 4
Session Date and Time: Tuesday Apr 18, 2023 from 1:30 PM ET – 5:00 PM ET
Location: Poster Section 40
Poster Board Number: 2
Published Abstract Number: 5545