On March 21, 2019 Heat Biologics,Inc. (NASDAQ: HTBX), a biopharmaceutical company developing immunotherapies designed to activate a patient’s immune system against cancer, reported an oral presentation to be held at the Chinese Society for Clinical Oncology (CSCO) Conference on Immunotherapy, endorsed by the American Association for Cancer Research (AACR) (Free AACR Whitepaper), taking place in Shanghai, China (Press release, Heat Biologics, MAR 21, 2019, View Source [SID1234534527]). The oral session will be held on March 22, 2019 from 17:00 China Standard Time. Management will present the interim results of the Phase 2 Lung Cancer Data on HS-110 + Nivolumab that were presented at the ASCO (Free ASCO Whitepaper)-SITC Clinical Immuno-Oncology Symposium on February 28, 2019.

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Details of the presentation are as follows:

Title: Viagenpumatucel-L (HS-110) plus nivolumab in patients with advanced non-small cell lung cancer (NSCLC)

Oral Session: March 22, 2019; 17:00 China Standard Time (March 22, 2019; 2:00 Pacific Time)

Location: Main Conference Room (Powerlong Ballroom), Le Meridien Shanghai Minhang Hotel, Shanghai, China

The AACR (Free AACR Whitepaper) is proud to work with the Chinese Society for Clinical Oncology (CSCO) and endorse this conference, which will take place on March 22-23, 2019, in Shanghai, China. The program will bring together researchers from the United States, China, and around the world to share the latest developments focusing on translational to clinical applications of immunotherapy with an emphasis on cancers with high incidence in the region. Each session will feature speakers from both China and abroad and offer ample opportunity to foster international scientific exchange.

On March 21, 2019 Altimmune, Inc. (Nasdaq: ALT), a clinical-stage immunotherapeutics company, reported that it will announce financial results for the year ended December 31, 2018 before the market open and host a conference call on Tuesday, April 2, 2019 (Press release, Altimmune, MAR 21, 2019, View Source [SID1234534545]).

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Conference Call Details
Date: Tuesday, April 2
Time: 8:30am Eastern Time
Domestic: 877-423-9813
International: 201-689-8573
Conference ID: 13687672
Webcast: View Source

On March 21, 2019 Epic Sciences, Inc. reported that new data will be presented at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2019, in Atlanta, Georgia, March 29 to April 4, 2019 (Press release, Epic Sciences, MAR 21, 2019, View Source [SID1234534564]). The data from multiple studies and indications demonstrate the feasibility of Epic’s Functional Cell Profiling (FCP) technology to predict patients’ response to cancer immunotherapies and drugs that target DNA damage repair pathways.

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Epic’s FCP technology platform identifies and characterizes all circulating tumor cells in a blood sample to link their response or resistance to several drug classes. Following the highly successful development of Epic’s proprietary AR-V7 test for patients with metastatic castration-resistant prostate cancer, currently marketed as the Oncotype DX AR-V7 Nucleus Detect test, the company and its research partners are utilizing the FCP platform to analyze biomarkers to guide treatment decisions in breast cancer and small-cell lung cancer, expanding into new areas of unmet need.

"For years, Epic Sciences has been transforming late-stage prostate cancer treatment with our powerfully predictive Functional Cell Profiling technology by providing a comprehensive view of how populations of cancer cells change under selective pressure of different drug classes," said Katherine Atkinson, Chief Commercial Officer at Epic Sciences. "At AACR (Free AACR Whitepaper), we are presenting new data that demonstrates our technology’s significant value can be applied to new indications and drug classes in development, in addition to late stage prostate cancer, potentially improving the lives of many more patients."

Following are the AACR (Free AACR Whitepaper) 2019 posters and presentations:

Oral Presentation:

Title: Liquid Biopsies: From Validation to Clinical Utility
Session Description: Discussion of the development and clinical application of validated circulating tumor cell (CTC) and cell-free DNA assays to determine prognosis, predict response to treatment, identify mechanisms of resistance to guide future treatment, and assess drug effects.
Chairperson & Presentation: Howard I. Scher, Memorial Sloan Kettering Cancer Center; Predictive biomarkers in circulating tumor cells to direct management of metastatic castration-resistant prostate cancer (mCRPC)
Session Date and Time: April 1, 2019, 2:05 pm – 2:30 pm ET

Poster Presentations:

Title: HER2, AR protein expression and chromosomal instability in circulating tumor cells (CTCs) of metastatic breast cancer (MBC) patients (pts)
Session Category and Title: Clinical Research: Current Developments in Non-invasive Biomarkers for Assessment of Cancer 1
Session Date and Time: Sunday, March 31, 2019 1:00 pm – 5:00 pm ET

Title: Genomic instability as a marker of poor prognosis in advanced prostate cancer: Subclonal insights from whole-genome sequencing of single circulating tumor cells
Session Category and Title: Clinical Research: Current Developments in Non-invasive Biomarkers for Assessment of Cancer 1
Session Date and Time: Sunday, March 31, 2019, 1:00 pm – 5:00 pm ET

Title: Characterization of SLFN11 protein expression in circulating tumor cells (CTCs) of patients with metastatic castration-resistant prostate cancer (mCRPC) prior to platinum based chemotherapy
Session Category and Title: Clinical Research: Circulating and Cell-free Biomarkers for Diagnosis and Monitoring of Cancer 2
Session Date and Time: Monday, April 1, 2019, 8:00 am – 12:00 pm ET

Title: Comparison of the Epic CTC HRD assay vs. tumor DDR mutations in metastatic castration-resistant prostate cancer (mCRPC) patients (pts)
Session Category and Title: Clinical Research: Circulating and Cell-free Biomarkers for Diagnosis and Monitoring of Cancer 3
Session Date and Time: Monday, April 1, 2019, 1:00 pm – 5:00 pm ET

Title: Single-cell analyses reveal increasing intratumoral heterogeneity as an essential component of treatment resistance in small-cell lung cancer
Session Category and Title: Tumor Biology: Tumor Evolution and Heterogeneity 1
Session Date and Time: Tuesday, April 2, 2019 8:00 am – 12:00 pm ET

Title: Evaluation of pharmacokinetics of proxalutamide, a novel androgen receptor antagonist, in treatment for mCRPC patients via CTC enumeration and AR biomarker analysis
Session Category and Title: Experimental and Molecular Therapeutics: Pharmacokinetics and Pharmacodynamics/Preclinical Toxicology
Session Date and Time: Tuesday, April 2, 2019, 1:00 pm – 5:00 pm ET

Title: Simultaneous quantification of activated immune cells and PD-L1 expressing circulating tumor cells (CTCs) in peripheral blood of cancer patients receiving checkpoint inhibitor therapy
Session Category and Title: Immunology: Biomarkers and Immune Monitoring
Session Date and Time: Tuesday, April 2, 2019, 1:00 pm – 5:00 pm ET

On March 21, 2019 BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a clinical-stage biopharmaceutical company focused on oncology, reported it will release its audited annual financial results for the year ended December 31, 2018 on Thursday, March 28, 2019, before the US markets open (Press release, BioLineRx, MAR 21, 2019, View Source;p=irol-newsArticle&ID=2391959 [SID1234534528]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The Company will host a conference call on Thursday, March 28, 2019 at 10:00 a.m. EDT featuring remarks by Philip Serlin, Chief Executive Officer. The conference call will be available via webcast and can be accessed through the Investor Relations page of BioLineRx’s website. Please allow extra time prior to the call to visit the site and download any necessary software to listen to the live broadcast.

To dial into the conference call, please dial +1-866-229-7198 from the U.S. or +972-3-918-0664 internationally. A replay of the conference call will be available approximately two hours after completion of the live conference call on the Investor Relations page of BioLineRx’s website. A dial-in replay of the call will be available until March 30, 2019; please dial +1-888-295-2634 from the U.S. or +972-3-925-5938 internationally

On March 21, 2019 Provectus (OTCQB: PVCT) reported that updates on the Company’s metastatic uveal melanoma drug development program for its lead investigational cancer agent PV-10 (Press release, Provectus Biopharmaceuticals, MAR 21, 2019, View Source [SID1234534529]). Intratumoral injection of small molecule oncolytic immunotherapy PV-10 can yield immunogenic cell death in solid tumor cancers and stimulate tumor-specific reactivity in circulating T cells1-4, which may lead to a functional recruitment of the immune system.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Update #1. Presentations about PV-10 treatment of metastatic uveal melanoma will be given by Sapna Patel, MD, Associate Professor, Department of Melanoma Medical Oncology, Division of Cancer Medicine of The University of Texas MD Anderson Cancer Center at:

The International Society of Ocular Oncology (ISOO) Biennial Conference in Los Angeles, California from March 22-26, entitled "Percutaneous oncolytic rose bengal disodium for metastatic uveal melanoma patients with hepatic metastasis." ISOO is a non-profit corporation with the specific and primary purpose to advance and promote the practice of ocular oncology, and

The spring meeting of the Ophthalmic Oncology Group (OOG) in London, England from April 11-13, entitled "A Phase 1 Study of Percutaneous Oncolytic Rose Bengal Disodium (PV10) for Metastatic Uveal Melanoma to the Liver." OOG is an independent scientific group devoted to clinical ophthalmic oncology and related basic-science research.
Update #2. The Company will host a round table involving metastatic uveal melanoma patients at CURE OM’s Eyes on a Cure: Patient & Caregiver Symposium in Raleigh, North Carolina from April 5-7. The Community United for Research and Education of Ocular Melanoma (CURE OM) is the Melanoma Research Foundation’s initiative to increase awareness, education, and research funding for ocular melanoma, while improving the lives of people affected by this disease.

Ocular melanoma is a general category of melanoma disease affecting the eye and orbit. Its most common form, uveal melanoma, is an intraocular affliction originating in melanocytes in the iris, ciliary body, or choroid. Together with melanomas that form in the conjunctiva, cornea, retina, and orbit, these melanomas constitute ocular melanoma. Approximately half of ocular melanoma patients develop metastatic disease despite successful treatment of their primary tumors. Metastatic disease has historically been, and remains, generally fatal.

About Metastatic Uveal Melanoma

Uveal melanoma is a rare disease that is biologically and clinically distinct from cutaneous melanoma.5,6 Nearly 50% of uveal melanoma patients develop metastatic disease, with 80-90% of them presenting with liver as the first site of disease involvement.5,6,7 Outcomes of metastatic uveal melanoma are poor, with a median overall survival of 12 months.8

About PV-10

Provectus’ lead investigational oncology drug, PV-10, the first small molecule oncolytic immunotherapy, can induce immunogenic cell death. PV-10 is undergoing clinical study for adult solid tumor cancers, like melanoma and cancers of the liver, and preclinical study for pediatric cancers. In February 2019, orphan drug designation status was granted to PV-10 by the U.S. Food and Drug Administration for the treatment of ocular melanoma.