On March 21, 2019 WARF Therapeutics reported a new partnership with Sanford Burnham Prebys Medical Discovery Institute (SBP) (Press release, WARF Therapeutics, MAR 21, 2019, View Source [SID1234644191]). SBP is an independent, nonprofit institution dedicated to understanding basic human biology and disease, and to advancing scientific discoveries to profoundly impact human health. SBP’s Conrad Prebys Center for Chemical Genomics (Prebys Center) is one of the most advanced drug discovery centers in the nonprofit world.

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WARF Therapeutics was established as a major new program of the Wisconsin Alumni Research Foundation (WARF) in 2018. Its mission is to identify promising biological discoveries on the UW-Madison campus that are relevant to human disease. WARF Therapeutics will invest in validated targets, design and develop drug-like molecules, and ultimately partner them with the venture capital community, pharmaceutical organizations and biotech companies. Jonathan Young, Ph.D., an industry veteran with over 20 years of experience in large pharma and biotech, was recently hired, after a nationwide search, to build and lead WARF Therapeutics.

Young says, "WARF’s collaboration with SBP will help us accelerate translation of promising research by providing the essential discovery and early development expertise required. Furthermore, this partnership will help WARF Therapeutics continue the legacy of pharmaceutical innovation at UW-Madison and ultimately deliver novel medicines to patients with unmet medical needs."

Under the terms of the 5-year agreement, WARF and UW-Madison scientists will work with scientists at SBP’s Prebys Center to transition clinically relevant targets to early-stage drug discovery, including assay development and high-throughput screening to identify chemical compounds that modulate the activity of the targets. The Prebys Center’s compound library is a collection of more than 1 million diverse chemicals. Validated "hits" from this library can be developed into prototype drugs.

"The Prebys Center is like a magnet that attracts collaborators and partnerships with like-minded researchers who seek to discover new therapeutics for diseases with serious clinical unmet needs," says Michael Jackson, Ph.D., senior vice president of drug discovery and development at SBP. "We look forward to a productive partnership with WARF that will lead to therapies for diseases in need of a cure."

SBP holds an analogous partnership with the Mayo Clinic that began in 2012. The Mayo-SBP agreement outlines efforts to build a pipeline of therapeutic drugs aimed at a variety of diseases with serious unmet clinical needs.

On March 21, 2019 Heat Biologics,Inc. (NASDAQ: HTBX), a biopharmaceutical company developing immunotherapies designed to activate a patient’s immune system against cancer, reported an oral presentation to be held at the Chinese Society for Clinical Oncology (CSCO) Conference on Immunotherapy, endorsed by the American Association for Cancer Research (AACR) (Free AACR Whitepaper), taking place in Shanghai, China (Press release, Heat Biologics, MAR 21, 2019, View Source [SID1234534527]). The oral session will be held on March 22, 2019 from 17:00 China Standard Time. Management will present the interim results of the Phase 2 Lung Cancer Data on HS-110 + Nivolumab that were presented at the ASCO (Free ASCO Whitepaper)-SITC Clinical Immuno-Oncology Symposium on February 28, 2019.

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Details of the presentation are as follows:

Title: Viagenpumatucel-L (HS-110) plus nivolumab in patients with advanced non-small cell lung cancer (NSCLC)

Oral Session: March 22, 2019; 17:00 China Standard Time (March 22, 2019; 2:00 Pacific Time)

Location: Main Conference Room (Powerlong Ballroom), Le Meridien Shanghai Minhang Hotel, Shanghai, China

The AACR (Free AACR Whitepaper) is proud to work with the Chinese Society for Clinical Oncology (CSCO) and endorse this conference, which will take place on March 22-23, 2019, in Shanghai, China. The program will bring together researchers from the United States, China, and around the world to share the latest developments focusing on translational to clinical applications of immunotherapy with an emphasis on cancers with high incidence in the region. Each session will feature speakers from both China and abroad and offer ample opportunity to foster international scientific exchange.

On March 21, 2019 Altimmune, Inc. (Nasdaq: ALT), a clinical-stage immunotherapeutics company, reported that it will announce financial results for the year ended December 31, 2018 before the market open and host a conference call on Tuesday, April 2, 2019 (Press release, Altimmune, MAR 21, 2019, View Source [SID1234534545]).

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Conference Call Details
Date: Tuesday, April 2
Time: 8:30am Eastern Time
Domestic: 877-423-9813
International: 201-689-8573
Conference ID: 13687672
Webcast: View Source

On March 21, 2019 Epic Sciences, Inc. reported that new data will be presented at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2019, in Atlanta, Georgia, March 29 to April 4, 2019 (Press release, Epic Sciences, MAR 21, 2019, View Source [SID1234534564]). The data from multiple studies and indications demonstrate the feasibility of Epic’s Functional Cell Profiling (FCP) technology to predict patients’ response to cancer immunotherapies and drugs that target DNA damage repair pathways.

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Epic’s FCP technology platform identifies and characterizes all circulating tumor cells in a blood sample to link their response or resistance to several drug classes. Following the highly successful development of Epic’s proprietary AR-V7 test for patients with metastatic castration-resistant prostate cancer, currently marketed as the Oncotype DX AR-V7 Nucleus Detect test, the company and its research partners are utilizing the FCP platform to analyze biomarkers to guide treatment decisions in breast cancer and small-cell lung cancer, expanding into new areas of unmet need.

"For years, Epic Sciences has been transforming late-stage prostate cancer treatment with our powerfully predictive Functional Cell Profiling technology by providing a comprehensive view of how populations of cancer cells change under selective pressure of different drug classes," said Katherine Atkinson, Chief Commercial Officer at Epic Sciences. "At AACR (Free AACR Whitepaper), we are presenting new data that demonstrates our technology’s significant value can be applied to new indications and drug classes in development, in addition to late stage prostate cancer, potentially improving the lives of many more patients."

Following are the AACR (Free AACR Whitepaper) 2019 posters and presentations:

Oral Presentation:

Title: Liquid Biopsies: From Validation to Clinical Utility
Session Description: Discussion of the development and clinical application of validated circulating tumor cell (CTC) and cell-free DNA assays to determine prognosis, predict response to treatment, identify mechanisms of resistance to guide future treatment, and assess drug effects.
Chairperson & Presentation: Howard I. Scher, Memorial Sloan Kettering Cancer Center; Predictive biomarkers in circulating tumor cells to direct management of metastatic castration-resistant prostate cancer (mCRPC)
Session Date and Time: April 1, 2019, 2:05 pm – 2:30 pm ET

Poster Presentations:

Title: HER2, AR protein expression and chromosomal instability in circulating tumor cells (CTCs) of metastatic breast cancer (MBC) patients (pts)
Session Category and Title: Clinical Research: Current Developments in Non-invasive Biomarkers for Assessment of Cancer 1
Session Date and Time: Sunday, March 31, 2019 1:00 pm – 5:00 pm ET

Title: Genomic instability as a marker of poor prognosis in advanced prostate cancer: Subclonal insights from whole-genome sequencing of single circulating tumor cells
Session Category and Title: Clinical Research: Current Developments in Non-invasive Biomarkers for Assessment of Cancer 1
Session Date and Time: Sunday, March 31, 2019, 1:00 pm – 5:00 pm ET

Title: Characterization of SLFN11 protein expression in circulating tumor cells (CTCs) of patients with metastatic castration-resistant prostate cancer (mCRPC) prior to platinum based chemotherapy
Session Category and Title: Clinical Research: Circulating and Cell-free Biomarkers for Diagnosis and Monitoring of Cancer 2
Session Date and Time: Monday, April 1, 2019, 8:00 am – 12:00 pm ET

Title: Comparison of the Epic CTC HRD assay vs. tumor DDR mutations in metastatic castration-resistant prostate cancer (mCRPC) patients (pts)
Session Category and Title: Clinical Research: Circulating and Cell-free Biomarkers for Diagnosis and Monitoring of Cancer 3
Session Date and Time: Monday, April 1, 2019, 1:00 pm – 5:00 pm ET

Title: Single-cell analyses reveal increasing intratumoral heterogeneity as an essential component of treatment resistance in small-cell lung cancer
Session Category and Title: Tumor Biology: Tumor Evolution and Heterogeneity 1
Session Date and Time: Tuesday, April 2, 2019 8:00 am – 12:00 pm ET

Title: Evaluation of pharmacokinetics of proxalutamide, a novel androgen receptor antagonist, in treatment for mCRPC patients via CTC enumeration and AR biomarker analysis
Session Category and Title: Experimental and Molecular Therapeutics: Pharmacokinetics and Pharmacodynamics/Preclinical Toxicology
Session Date and Time: Tuesday, April 2, 2019, 1:00 pm – 5:00 pm ET

Title: Simultaneous quantification of activated immune cells and PD-L1 expressing circulating tumor cells (CTCs) in peripheral blood of cancer patients receiving checkpoint inhibitor therapy
Session Category and Title: Immunology: Biomarkers and Immune Monitoring
Session Date and Time: Tuesday, April 2, 2019, 1:00 pm – 5:00 pm ET

On March 21, 2019 BioLineRx Ltd. (NASDAQ: BLRX) (TASE: BLRX), a clinical-stage biopharmaceutical company focused on oncology, reported it will release its audited annual financial results for the year ended December 31, 2018 on Thursday, March 28, 2019, before the US markets open (Press release, BioLineRx, MAR 21, 2019, View Source;p=irol-newsArticle&ID=2391959 [SID1234534528]).

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The Company will host a conference call on Thursday, March 28, 2019 at 10:00 a.m. EDT featuring remarks by Philip Serlin, Chief Executive Officer. The conference call will be available via webcast and can be accessed through the Investor Relations page of BioLineRx’s website. Please allow extra time prior to the call to visit the site and download any necessary software to listen to the live broadcast.

To dial into the conference call, please dial +1-866-229-7198 from the U.S. or +972-3-918-0664 internationally. A replay of the conference call will be available approximately two hours after completion of the live conference call on the Investor Relations page of BioLineRx’s website. A dial-in replay of the call will be available until March 30, 2019; please dial +1-888-295-2634 from the U.S. or +972-3-925-5938 internationally