On May 21, 2026 Sapience Therapeutics, Inc., a clinical-stage biotechnology company focused on the discovery and development of peptide therapeutics to address oncogenic and immune dysregulation that drive cancer, reported updated positive clinical and pharmacodynamic data from its Phase 2 clinical trial of lucicebtide, a first-in-class antagonist of C/EBPβ, alone or in combination with chemoradiation standard-of-care (SOC) in patients with glioblastoma (GBM) at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place May 29-June 2, 2026, in Chicago and online.

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Despite being the most common and lethal malignant brain tumor, with more than 14,000 patients diagnosed each year in the United States, GBM remains an underserved disease, with limited progress in overall survival for patients over the last 20 years.1 C/EBPβ drives tumor growth and survival, and is a master regulator of the mesenchymal transformation in GBM, a state associated with chemotherapy resistance and aggressive disease, supporting it as a compelling therapeutic target for GBM. C/EBPβ is also recognized as regulating an immune-suppressive program in tumor-associated macrophages that contributes to tumor growth and progression. 2,3

Sapience’s ongoing Phase 2 Window-of-Opportunity study is evaluating lucicebtide alone or in combination with SOC in patients with GBM, with dosing administered before and after surgical resection. Nine patients are evaluable for analysis. As of April 27, 2026:

Patients with ndGBM treated with lucicebtide in combination with SOC achieved PFS and OS outcomes that exceed those reported in the published literature
Projected mPFS of 28.4 months meaningfully exceeds the 4.0 to 6.9-month historic benchmark range 4,5
mOS not yet reached; 6 of 9 patients remain alive beyond 22.3 months (per the cutoff date), exceeding the 14.6 to 17.0-month historic benchmark range 4,6
Lucicebtide activity is further demonstrated by on-target clinical pharmacodynamics
Target engagement confirmed via negative enrichment of C/EBPβ regulon in tumor and myeloid cells
Suppression of the mesenchymal GBM transformation observed by spatial transcriptomics analysis
Lucicebtide is well tolerated, with no DLTs or related SAEs observed
"The ASCO (Free ASCO Whitepaper) 2026 lucicebtide dataset continues to reinforce our conviction in the strength of this program," said Barry Kappel, Ph.D., Sapience’s Chief Executive Officer. "The maturing results show durable progression free and overall survival improvements, and clearly position lucicebtide as a promising, well‑tolerated therapy with the potential to elevate the standard of care in GBM. We are eager to advance this program to bring meaningful progress to patients and families affected by this devastating disease."

Details of the presentation are as follows:

Title: "Lucicebtide (ST101) Plus Chemoradiation in Newly Diagnosed GBM Patients: Efficacy, Pharmacodynamics, and Safety in Phase 2 Window-of-Opportunity Study"
Session Title: Poster Session – Central Nervous System Tumors
Poster Board: 444
Date and Time: Monday, June 1, 2026, 1:30 PM-4:30 PM CDT

More information can be found on the ASCO (Free ASCO Whitepaper) Annual Meeting 2026 website.

About Lucicebtide (formerly known as ST101)
Lucicebtide is a first-in-class peptide antagonist of CCAAT/enhancer-binding protein β (C/EBPβ), a transcription factor that drives tumor aggressiveness, immune evasion and therapy resistance in GBM. Lucicebtide has been studied in 125 patients and is observed to be safe, well-tolerated and clinically active both as a monotherapy in recurrent GBM (rGBM) and in combination with SOC chemoradiation in ndGBM. Lucicebtide was designed with a cell-penetration domain that enables it to cross the blood-brain barrier and enter the nucleus of cells, and a binding domain that specifically interacts with C/EBPβ, preventing it from dimerizing to an active state and driving it to be degraded by the cell’s own machinery.7 Lucicebtide has been granted Fast Track designation for rGBM from the U.S. Food and Drug Administration (U.S. FDA) and orphan designations for glioma from the U.S. FDA and the European Commission.

About the Lucicebtide Window-of-Opportunity Study
Lucicebtide has completed the main portion of a Phase 2 dose expansion study in rGBM (NCT04478279). An ongoing Window-of-Opportunity sub-study is evaluating lucicebtide in combination with radiation and temozolomide in patients with newly diagnosed GBM (ndGBM) and as a monotherapy in patients with rGBM, with patients receiving lucicebtide before and after surgical resection in both cohorts.

(Press release, Sapience Therapeutics, MAY 21, 2026, View Source [SID1234665964])

On May 21, 2026 Perspective Therapeutics, Inc. ("Perspective" or the "Company") (NYSE AMERICAN: CATX), a radiopharmaceutical development company pioneering advanced treatments for cancers throughout the body, reported that updates on all three of its advancing clinical programs, [²¹²Pb]VMT-α-NET, [²¹²Pb]VMT01, and [²¹²Pb]PSV359, will be presented at the 2026 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting taking place from May 29 to June 2, 2026 in Chicago, IL.

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2026 ASCO (Free ASCO Whitepaper) Poster Presentation Highlights and Details

[212Pb]VMT-α-NET for Neuroendocrine Tumors – Updated Phase 1/2a data show:

Clinical profile being reported is consistent with previously disclosed findings at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026 (AACR 2026)
Deepening of response continues to be observed since the AACR (Free AACR Whitepaper) 2026 and the European Society for Medical Oncology Congress 2025 (ESMO 2025) presentations
The ASCO (Free ASCO Whitepaper) data cut-off date of April 17, 2026 represents an additional ~6 weeks of follow-up since the prior update at AACR (Free AACR Whitepaper) 2026 in April 2026 and ~31 weeks since ESMO (Free ESMO Whitepaper) 2025 in October 2025

[²¹²Pb]VMT01 for Melanoma – 3.0 mCi monotherapy (n=7) and nivolumab combination (n=6) cohorts are ongoing in the Phase 1/2a study in positive melanocortin 1 receptor (MC1R)-targeted, heavily pre-treated melanoma.

As of the March 25, 2026 data cut-off date:
One new response was observed early in the 3.0 mCi monotherapy cohort, in addition to a previously reported response, for a total of two responders out of seven treated patients
Six patients (86%) experienced stable disease or partial response out of the seven patients in the 3.0 mCi monotherapy cohort; four patients completed all three treatments with 24 weeks or more of follow-up since their first treatment, and two remain on treatment and in study
[²¹²Pb]VMT01 was well-tolerated with no dose limiting toxicities (DLTs), no discontinuations due to adverse events, and no Grade 4 or Grade 5 treatment emergent adverse events (TEAEs)
Eight (30%) patients out of a total of 27 patients treated experienced Grade 3 TEAEs
[²¹²Pb]PSV359 for Solid Tumors – Treatments in Cohort 3 (6.0 mCi) initiated in May 2026 in the Phase 1/2a study in solid tumors that express fibroblast activation protein alpha (FAP-α).

[212Pb]PSV359 was well-tolerated with no DLTs, and TEAEs at Grades 1 and 2 only, as of the data cut-off date of December 24, 2025

Presenter Abstract Title Presentation Details
Thorvardur Halfdanarson,
Mayo Clinic Comprehensive Cancer Center

Cohort-level safety and efficacy results for [212Pb]VMT-α-NET in advanced somatostatin receptor subtype 2 (SSTR2+)–expressing neuroendocrine tumors (NETs): Cohorts 1–3 Abstract Number: 4173
Session Title: Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary
Date and Time: May 30, 2026, 9:00 am – 12:00 pm CDT
Zachary Morris, University of Wisconsin School of Medicine and Public Health A phase I/IIa, first-in-human, multicenter, monotherapy and combination-therapy with nivolumab, dose-finding of [212Pb]VMT01 melanocortin-1-receptor-targeted, image-guided, alpha-particle therapy in subjects with previously treated unresectable or metastatic melanoma

Abstract Number: 9525
Session Title: Melanoma/Skin Cancers
Date and Time: May 31, 2026, 9:00 a.m. – 12:00 p.m. CDT

Samuel Mehr, Nebraska Cancer Specialists

A phase I/IIa, image-guided, alpha-particle therapy study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in patients with solid tumors that are known to be fibroblast activation protein (FAP)-positive

Abstract Number: e15146
Session Type: Publication Only

About [212Pb]VMT-α-NET

Perspective designed [212Pb]VMT-α-NET to target and deliver 212Pb to tumor sites expressing somatostatin receptor type 2 (SSTR2). The Company is conducting a multi-center, open-label, dose-escalation, dose-expansion study (clinicaltrials.gov identifier NCT05636618) of [212Pb]VMT-α-NET in patients with unresectable or metastatic SSTR2-positive neuroendocrine tumors who have not received prior radiopharmaceutical therapies (RPT).

Interim analysis with a data cut-off date of March 4, 2026 was recently reported at AACR (Free AACR Whitepaper) 2026 in April 2026, including efficacy data on half of the patients in Cohort 2 and both patients in Cohort 1. Initial efficacy data for the remaining patients in Cohort 2 and eight patients in Cohort 3 are pending, and submissions for presentations at additional medical conferences during 2026 are planned.

Highlights from the recently presented AACR (Free AACR Whitepaper) analysis included the following:

As of the data cut-off date of March 4, 2026:

Safety findings based on 64 patients who received at least one treatment:

The 64 patients in this safety analysis comprised two patients in Cohort 1 (2.5 mCi), 46 patients in Cohort 2 (5.0 mCi), and 16 patients in Cohort 3 (6.0 mCi).
There were no reports of DLTs, treatment-related discontinuations, serious renal complications, dysphagia, or clinically significant treatment-related myelosuppression.
Grade 3 or higher treatment-emergent adverse events were reported in 23 patients (36%). One of these patients, who was enrolled in Cohort 3, experienced a transient lymphocyte count decrease on the cusp of Grades 3 and 4. This event was subsequently determined by the site to be a Grade 3 event. This event was transient and resolved without medical intervention. The patient completed the full course of [212Pb]VMT-α-NET treatment of four treatments without interruption and remains on study. Otherwise, no Grade 4 or Grade 5 events have occurred.
No additional patients experienced serious adverse events (SAEs) since the most recent data update at the 2026 ASCO (Free ASCO Whitepaper) Gastrointestinal Cancers Symposium in January 2026 (ASCO-GI 2026), with none of the five SAEs deemed related to the study medication.

Anti-tumor activity based on both patients in Cohort 1 and 23 patients in Cohort 2:

Updated efficacy analysis in the same 25 patients from ASCO (Free ASCO Whitepaper)-GI 2026 and ESMO (Free ESMO Whitepaper) 2025 was presented with an additional ~12 weeks and ~25 weeks of follow-up, respectively.
18 of the 25 patients (72%) were without progression and remained alive, including both patients in Cohort 1.
Ten (43%) patients in Cohort 2 were observed to have response according to investigator-assessed RECIST v1.1. Nine of those responses were previously reported at ASCO (Free ASCO Whitepaper)-GI 2026, including one initial response reported at ASCO (Free ASCO Whitepaper)-GI 2026 that has since been confirmed. Since then, one more patient experienced an initial response in their most recent tumor assessment. As the patient remains on study, the patient is expected to receive a subsequent tumor assessment.
Eight (50%) of the 16 patients in Cohort 2 whose tumors all express SSTR2 were observed to have response according to investigator-assessed RECIST v1.1.
Nine patients were observed to have deepening of best response since initial tumor assessments on these patients were reported at ESMO (Free ESMO Whitepaper) in October 2025.

About [212Pb]VMT01
Perspective designed [212Pb]VMT01 to target and deliver 212Pb to tumor sites expressing MC1R, a protein that can be overexpressed in metastatic melanoma tumors.1 The Company is conducting a multi-center, open-label dose escalation, dose expansion study (clinicaltrials.gov identifier NCT05655312) in patients with histologically confirmed melanoma and MC1R-positive imaging scans. In September 2024, the Company announced that the U.S. Food and Drug Administration (FDA) granted Fast Track Designation for the development of [212Pb]VMT01 for the diagnosis and treatment of patients with unresectable or metastatic melanoma and who have demonstrated MC1R tumor expression. The FDA’s Fast Track Designation is one of several approaches utilized by the FDA to expedite development and review of potential medicines for serious conditions and that fulfill unmet medical needs.2

About PSV359
PSV359 was designed to target and deliver 212Pb to tumor sites expressing FAP-α, associated with multiple highly prevalent solid tumors, with patients in need of additional treatment options. The targeting moiety may also be radiolabeled with 203Pb or 68Ga (known as PSV377) to detect FAP-α expression in individual patients. Preclinical imaging and therapy as well as human imaging results suggest Perspective’s proprietary targeting ligand has improved levels of target engagement and uptake in tumors, as well as reduced retention in healthy tissues, which may result in a desirable therapeutic index.

Perspective is conducting a multi-center, open-label, dose-finding and dose-expansion study (clinicaltrials.gov identifier NCT06710756) of [212Pb]PSV359 in patients with advanced solid tumors that express FAP-α as determined by imaging with [203Pb]PSV359. The primary objective of the dose finding phase of the study is to assess the safety and tolerability of various doses of [212Pb]PSV359 in order to determine the recommended Phase 2 dose to be used in the expansion phase of the study, where anti-tumor activities may be an additional primary outcome measure.

(Press release, Perspective Therapeutics, MAY 21, 2026, View Source [SID1234665980])

On May 21, 2026 Revolution Medicines, Inc. (Nasdaq: RVMD), a late-stage clinical oncology company developing targeted therapies for patients with RAS-addicted cancers, reported that members of Revolution Medicines’ senior management team will host a webcast on Sunday, May 31 at 7:00 pm ET to discuss positive results from the Phase 3 RASolute 302 clinical trial evaluating daraxonrasib in patients with previously treated metastatic pancreatic ductal adenocarcinoma (PDAC) following presentation of the data during the Plenary Session at the 2026 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting.

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To listen to the live webcast, or access the archived webcast, please visit: View Source Following the live webcast, a replay will be available on the company’s website for at least 14 days.

(Press release, Revolution Medicines, MAY 21, 2026, View Source [SID1234665996])

On May 21, 2026 AN2 Therapeutics, Inc. (Nasdaq: ANTX), a biopharmaceutical company advancing novel small molecule therapeutics derived from its boron chemistry platform, reported that Eric Easom, Co-Founder, Chairman, President and CEO will present at the 2026 Jefferies Global Healthcare Conference on June 4, 2026 at 12:50 PM ET, and members of management will be available for 1×1 meetings.

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A webcast can be accessed on the Investors section of the AN2 Therapeutics website at www.an2therapeutics.com. An archived replay will be available for at least 30 days following the presentation.

(Press release, AN2 Therapeutics, MAY 21, 2026, View Source [SID1234665915])

On May 21, 2026 Lantheus Holdings, Inc. (the Company) (NASDAQ: LNTH), the leading radiopharmaceutical-focused company committed to enabling clinicians to Find, Fight and Follow disease to deliver better patient outcomes, reported new radiodiagnostic data to be presented at the 2026 Society of Nuclear Medicine and Medical Imaging (SNMMI) Annual Meeting, taking place May 30 – June 2, 2026 in Los Angeles, CA.

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Presentation details are as follows:

Date & Time: Monday, June 1, 2026, 10:30 am – 11:15 am PT

Session Type: Poster
Session Title: Oncology Clinical Diagnosis and Therapy Scientific Session

Session Number: MTA06 – Screen 29
Title: Impact of PSMA-PET with Piflufolastat F18 on Prostate Cancer Management for Patients with Low or Ultra-low Prostate-Specific Antigen Levels after Definitive Treatment.
Presenter: Neal Shore, Carolina Urologic Research Center
Poster Number: #262453

Date & Time: Tuesday, June 2, 2026, 9:50 am – 10:00 am PT
Session Type: Oral Presentation

Session Title: Prognosis and Novel Imaging Techniques
Session Number: SS30

Location: SS Room 2

Title: Diagnostic performance of 18F-GP1 PET/CT for acute deep vein thrombosis of the lower extremities in symptomatic patients: a phase 2, open-label, non-randomized study
Presenter: Sangwon Han, Asan Medical Center, University of Ulsan College of Medicine

(Press release, Lantheus, MAY 21, 2026, View Source [SID1234665933])