Entry into a Material Definitive Agreement

On December 16, 2020, Cannabics Pharmaceuticals Inc. (the "Company") reported that it entered into a Securities Purchase Agreement (the "SPA") with an institutional investor (the "investor" or a "holder") to sell a new series of senior secured convertible notes (the "Convertible Notes") of the Company in a four tranche private placement (the "Private Placement") to the investor, with an aggregate principal amount of $2,750,000 having an aggregate original issue discount of 10%, and ranking senior to all outstanding and future indebtedness of the Company (Filing, 8-K, Cannabics Pharmaceuticals, DEC 16, 2020, View Source [SID1234573192]). Pursuant to the SPA, one Convertible Note (the "Initial Note") in an aggregate original principal amount of $825,000 will be issued to the investor in the first tranche in reliance upon the exemption from securities registration afforded by Section 4(a)(2) of the Securities Act of 1933, as amended (the "1933 Act"), and Rule 506(b) of Regulation D ("Regulation D") as promulgated by the United States Securities and Exchange Commission (the "SEC") under the 1933 Act, together with the issuance of warrants (the "Warrants" and, together with the Convertible Note, the "Securities") to acquire our common stock , as described below. The Initial Note has a face amount of $825,000 for which the Company shall receive cash proceeds of $750,000. Subject to the satisfaction of customary closing and equity conditions, at any time prior to December 31, 2021 (or such later date as the parties shall mutually agree), the Company has the right to require additional closings of tranches of additional notes (the "Additional Notes", and together with the Initial Notes, the "Notes") as follows: (x) $825,000 in aggregate principal of Additional Notes upon the effectiveness of a registration statement with respect to the shares of our common stock issuable upon conversion of the Notes (or, if earlier the date such underlying shares of our common stock are initially available to be resold pursuant to Rule 144 of the Securities Act of 1933, as amended (or if later, such date as the Company is then current in its public filings)) (the "Applicable Date"), (y) $550,000 in aggregate principal of Additional Notes upon the 90th calendar day anniversary of the Applicable Date and (z) $550,000 in aggregate principal of Additional Notes upon the 180th calendar day anniversary of the Applicable Date s. The Convertible Notes are being sold with an original issue discount of 10% and do not bear interest except upon the occurrence of an event of default.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The following descriptions of the Convertible Notes, Warrants, Security and Pledge Agreement, Guaranty, Registration Rights Agreement and SPA are not complete and are qualified in their entirety by reference to the full text of such agreements, the forms of which are attached as Exhibit 10.1 through 10.6 to this Form 8-K, respectively.

Transgene Announces Investor Meetings for January 2021

On December 16, 2020 Transgene (Paris:TNG) (Euronext Paris: TNG) reported that Management will participate in the upcoming investor events set out below (Press release, Transgene, DEC 16, 2020, View Source [SID1234572949]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Transgene will meet institutional investors at the 10th Annual LifeSci Advisors Corporate Access Event (virtual event) from January 6th to 14th, 2021 in conjunction with the J.P. Morgan Healthcare conference.

The Company will also attend:

Oddo BHF Digital Forum: January 7 to 13, 2021
Biomed Event (virtual event): January 26 & 27, 2021

TRIUMF Enters Collaboration with Fusion Pharmaceuticals to Boost Production of Actinium-225, a Cancer-Fighting Medical Isotope

On December 16, 2020 TRIUMF, Canada’s particle accelerator centre, reported it has entered into a collaboration agreement with Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines (Press release, Fusion Pharmaceuticals, DEC 16, 2020, View Source [SID1234573117]). Under the agreement, Fusion will provide a financial investment enabling TRIUMF to upgrade its actinium-225 production infrastructure, and in return will receive preferred access to actinium-225, a rare medical isotope that shows great promise in new, cutting-edge cancer therapies.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

An alpha-emitting isotope with a short half-life, actinium-225 can be combined with a molecular agent that specifically targets cancer cells, seeking out and destroying the cancer while leaving the surrounding tissue unharmed. The new collaboration will enable TRIUMF to significantly increase its production and delivery of actinium-225.

"Today’s announcement marks an important step in positioning Canada to play a leading role in the development and deployment of next-generation radiotherapies, and in ensuring that researchers and patients around the world have a stable supply of life-saving medical isotopes," said Dr. Jonathan Bagger, Director of TRIUMF. "Enabled by decades of public investment in TRIUMF’s infrastructure and research programs, this collaboration recognizes the laboratory’s capacity to drive innovation, moving this promising treatment closer to market."

"Given Fusion’s opportunity to expand our pipeline of actinium-based Targeted Alpha Therapies (TATs), and the importance of isotope production in the supply chain of radiopharmaceuticals, we will continue to proactively address and prioritize actinium supply in our strategic plans," said Dr. John Valliant, Chief Executive Officer of Fusion. "We are excited to collaborate with TRIUMF, a leader in isotope production, as part of these plans."

"With its Targeted Alpha Therapy platform technology, Fusion has an opportunity to impact the cancer treatment landscape," said Kathryn Hayashi, Chief Executive Officer of TRIUMF Innovations. "Through this collaboration agreement, we are partnering with a premier developer of innovative radiotherapies to deepen TRIUMF’s leadership position in isotope production to help save the lives of patients in Canada and around the world".

Seagen to Present at the J.P. Morgan Healthcare Conference

On December 16, 2020 Seagen Inc. (Nasdaq: SGEN) reported that management will present at the 39th Annual J.P. Morgan Virtual Healthcare Conference on Monday, January 11, 2021 at 2:00 p.m. Eastern Time (Press release, Seagen, DEC 16, 2020, View Source [SID1234572934]). The presentation will be webcast live and available for replay from Seagen’s website at www.seagen.com in the Investors section.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!


New Research Suggests Multi-Cancer Early Detection Blood Test Could Reduce Late-Stage Cancer Diagnoses by More Than Half

On December 16, 2020 GRAIL, Inc., a healthcare company whose mission is to detect cancer early,reported that new analyses estimating the potential of GRAIL’s multi-cancer early detection blood test to find more cancers earlier and save lives (Press release, Grail, DEC 16, 2020, View Source [SID1234572950]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research (AACR) (Free AACR Whitepaper), the analysis used epidemiologic modeling to estimate the potential impact of adding an annual multi-cancer early detection blood test, such as GRAIL’s Galleri, to standard of care cancer screenings. The model estimates a potential reduction in late-stage (stage III and IV) cancer diagnoses by more than half in the U.S. population, aged 50-79. This decrease in late-stage diagnoses could translate to a reduction in five-year cancer deaths by 39% among those detected earlier, equating to an overall reduction of all five-year cancer deaths by 26%.

Today, the majority of cancers are found too late when outcomes are often fatal, because most deadly cancers have no available screening tests. Current guideline-recommended screenings are critical, but in the U.S. they cover only five cancers and screen for a single cancer at a time. Cancers responsible for nearly 71% of cancer deaths have no recommended early detection screening.

In clinical validation studies, an earlier version of Galleri demonstrated the ability to detect more than 50 types of cancers — over 45 of which lack recommended screening tests in the U.S. — with a low false positive rate of less than 1%. When a cancer was detected, the test also determined where in the body the cancer signal was located with high accuracy, all from a single blood draw.

"What we learned through this advanced modeling analysis is that GRAIL’s multi-cancer early detection test, based on identifying methylation signals in the circulating DNA, has the potential to substantially reduce overall cancer deaths," said Joshua Ofman, MD, MSHS, Chief Medical Officer and External Affairs at GRAIL. "A simple blood test like Galleri, that can detect more than 50 types of cancers and dramatically increase the cancer detection rate in the population, holds great potential to improve public health and save lives."

The cancer "interception model" — as the researchers describe it — uses published test performance data from GRAIL’s foundational Circulating Cell-free Genome Atlas (CCGA) study, including the cancer detection rate across all stages. It employs data from the U.S. Surveillance, Epidemiology, and End Results (SEER) program to quantify the stages at which cancers are currently diagnosed to understand the total number of cancers detected, and the potential reductions — or interceptions — in late-stage cancer diagnoses and associated deaths that could occur by adding GRAIL’s multi-cancer early detection test to standard of care cancer screenings in the U.S population, ages 50-79.

"Nearly all prior modeling efforts have focused on single cancer screening programs, leaving a gap in models addressing the potential population health benefits of multi-cancer early detection," said Christine D. Berg, MD, Special Volunteer, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. "Nothing like GRAIL’s test exists today, making rigorous modeling our current best approach to quantify the magnitude of the potential impact this innovative genomic technology could have on people across the U.S. through earlier cancer detection."

Galleri is expected to be available in the U.S. in 2021 and is currently available under investigational use in GRAIL’s first interventional study, PATHFINDER, where it is being used to guide clinical care. Galleri is also expected to be offered to patients in the United Kingdom (UK) starting in 2021 as part of a partnership with the UK’s National Health Service to support its Long Term Plan for earlier cancer diagnoses in an effort to transform cancer outcomes.