On March 31, 2017 MacroGenics, Inc. (NASDAQ: MGNX), a clinical-stage biopharmaceutical company focused on discovering and developing innovative monoclonal antibody-based therapeutics for the treatment of cancer, as well as autoimmune disorders and infectious diseases, reported the presentation of eight nonclinical posters based on its molecules and antibody-based technologies at the 2017 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting in Washington, D.C (Press release, MacroGenics, MAR 31, 2017, View Source [SID1234518363]). Three of these posters are being presented by the Company’s collaboration partners, Janssen Research & Development, LLC and ImmunoGen, Inc.
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"MacroGenics’ record of antibody-based therapeutic innovation continues," said Scott Koenig, M.D., Ph.D., President and CEO of MacroGenics. "Beyond our broad, growing pipeline of clinical assets across immuno-oncology and autoimmune disorders today, we have maintained our investment in preclinical research to yield our future product candidates for delivering therapeutics to patients in need. The posters featured at AACR (Free AACR Whitepaper) reflect advances in our DART and TRIDENT multi-specific platform technologies, including the ability to target multiple checkpoints with a single recombinant molecule and T cell-mediated cytotoxic mechanisms as well as the deployment of multiple linker-drug conjugate technologies with novel cancer targets. I’m very excited about the potential for each of these programs."
MacroGenics AACR (Free AACR Whitepaper) 2017 Poster Presentations
Each of the posters featured at AACR (Free AACR Whitepaper) relating to a MacroGenics-developed molecule are described below and after their presentation at AACR (Free AACR Whitepaper), may be accessed under "Events & Presentations" in the Investors section of the Company’s website at View Source
B7-H3-targeted Antibody-drug Conjugate: "Preclinical Development of a Duocarmycin-Based Antibody-Drug Conjugate (ADC) Targeting B7-H3 for Solid Cancer" (presentation date is Sunday, April 2 from 1:00 — 5:00pm ET; poster section 2, board #23).
ADAM9 ADC: "ADAM9: Target Validation, Antibody Discovery and Preclinical Data Supporting ADAM9 as an Antibody-Drug Conjugate Therapeutic Target for Solid Tumors" (presentation date is Sunday, April 2 from 1:00 — 5:00pm ET; poster section 2, board #19).
ADAM9 ADC: "Novel Antibody-Drug Conjugates Targeting ADAM9-expressing Solid Tumors Demonstrate Potent Preclinical Activity" (presentation date is Sunday, April 2 from 1:00 — 5:00pm ET; poster section 2, board #18). This poster is being presented by ImmunoGen, Inc.
CD137 DART: "Tumor-Antigen Expression-Dependent Activation of the CD137 Costimulatory Pathway by Bispecific DART Proteins" (presentation date is Tuesday, April 4 from 8:00am — 12:00pm ET; poster section 26, board #15).
PD-1 x CTLA-4 DART: "Co-targeting PD-1 and CTLA-4 Inhibitory Pathways with Bispecific DART and TRIDENT Molecules" (presentation date is Tuesday, April 4 from 8:00am — 12:00pm ET; poster section 26, board #10).
Duvortuxizumab (MGD011): "Potent Antitumor Activity of Duvortuxizumab, a CD19 x CD3 DART Molecule, in Lymphoma Models" (presentation date is Tuesday, April 4 from 8:00am — 12:00pm ET; poster section 26, board #9). This poster is being presented by Janssen.
Duvortuxizumab (MGD011): "Quantitative Prediction of Human Pharmacokinetics for Duvortuxizumab from Cynomolgus Monkey Data: a Translational Pharmacokinetic Modeling Approach" (presentation date is Tuesday, April 4 from 1:00 — 5:00pm ET; poster section 3, board #29). This poster is being presented by Janssen.
5T4 x CD3 DART: "A 5T4 x CD3 Bispecific DART Molecule with Extended Half-life for T-cell Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)s" (presentation date is Tuesday, April 4 from 1:00 — 5:00pm ET; poster section 26, board #23).