On February 28, 2017 GigaGen Inc., a biopharmaceutical company with patented technology for discovery of antibody therapeutics from millions-diverse immune repertoires, reported a strategic partnership with Trianni, Inc., a biotechnology company that has developed novel mouse strains genetically engineered to express human antibodies (Press release, GigaGen, FEB 28, 2017, View Source [SID1234520618]). The partnership will use GigaGen technology to discover immuno-oncology antibody therapeutics through The Trianni Mouse platform.
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"The combined power of the Trianni and GigaGen technologies will produce an unprecedented pipeline of fully-human antibodies," said Dave Johnson, PhD, MBA, CEO of GigaGen. "We are confident that the resulting portfolio will have an enormous impact on the field of immuno-oncology."
The Trianni Mouse has been engineered with genetic loci that are optimized for the expression of antibodies that are entirely human in their variable domains. Because they retain mouse constant regions in their antibody repertoires, the mice are not immunocompromised, but rather exhibit robust lymphocyte development and immune responses.
GigaGen’s highly efficient immune repertoire sequencing and expression platform captures full B-cell repertoires and then builds protein display libraries from the repertoires to rapidly validate binding and function. Using GigaGen’s technology, a single mouse produces hundreds or thousands of therapeutic candidates, which are rapidly sequenced and validated for binding affinity.
"We are excited to put The Trianni Mouse into the hands of our partners at GigaGen," said David Meininger, PhD, MBA, CBO of Trianni. "In prior roles in research and in business development, I evaluated many antibody discovery technologies, and believe that GigaGen and Trianni have transformative technologies that together offer enormous potential to rapidly identify new immuno-oncology treatments."
About Trianni, Inc.
Trianni is a privately held organization, formed in 2010, with a mission to use recent advances in DNA synthesis and genomic modification technology for the development of an optimized therapeutic antibody discovery platform, The Trianni Mouse. The company is headquartered in San Francisco, CA.