On October 21, 2020 GT Biopharma, Inc. (OTCQB:GTBP) (GTBP.PA) an immuno-oncology company focused on innovative therapies based on the Company’s proprietary NK cell engager (TriKE) technology reported the publication of "NK-Cell-Mediated Targeting of Various Solid Tumors Using a B7-H3 Tri-Specific Killer Engager In Vitro and In Vivo" in the journal Cancers, volume 12, issue 9, page 2659; (View Source) (Press release, GT Biopharma, OCT 21, 2020, View Source [SID1234568724]). The research effort was conducted by researchers at the University of Minnesota and at Massachusetts General Hospital/Harvard Medical School.

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B7H3 (CD276) is a costimulatory membrane protein, and a member of the B7 family of costimulatory membrane proteins which include PD-1, PD-L1 and CTLA-4. B7 family members such as PD-1/PD-L1 and CTLA-4 play important roles in the checkpoint blockade of immune cells by cancer cells. B7H3 is highly expressed on the surface of several types of cancer, and exhibits low expression on normal tissues. The findings presented indicate that a B7H3-targeted TriKE has the potential to enhance natural killer (NK) cell immunotherapy in solid tumor settings, and supports its further clinical development.

Mr. Anthony Cataldo, the Chairman and Chief Executive Officer of GT Biopharma, commented "we are pleased with the results of the research, and expect to advance a B7H3 TriKE product candidate to clinical development."