On July 17, 2026 Immatics N.V. (NASDAQ: IMTX, "Immatics" or the "Company"), the global leader in precision targeting of PRAME with multiple clinical-stage programs spanning cell therapies and bispecifics, reported three presentations at the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Congress 2026, to be held from October 23-27, 2026, in Madrid, Spain.
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The three presentations will include:
Phase 1b data from anzu-cel, the Company’s lead PRAME cell therapy, in metastatic cutaneous and uveal melanoma, focusing on predictors of durable response
Phase 1 data from IMA203CD8 PRAME cell therapy across multiple PRAME-positive solid tumors, including durability follow-up at clinically relevant dose levels in gynecologic cancers, supporting the broad applicability of IMA203CD8 across diverse tumor types
Phase 1b data from IMA402, the Company’s PRAME bispecific, at recommended Phase 2 dose (RP2D) range across multiple cancers, supporting continued development in expansion cohorts and combination approaches
Collectively, these presentations highlight the breadth of Immatics’ PRAME franchise across two therapeutic modalities and a broad range of solid tumor indications.
Full abstracts will be published on the ESMO (Free ESMO Whitepaper) website on October 19, 2026, at 00:05 CEST.
Details on Oral and Poster Presentations
Title: Response durability with anzutresgene autoleucel (anzu-cel), a PRAME-directed T-cell receptor (TCR) T-cell therapy, in advanced melanoma
Presenting Author: Winfried Alsdorf, MD
Presentation Type: Poster presentation
Date / Time: October 24, 2026 / 12:00 – 12:45 CET
Presentation Number: 2128P
Title: Targeting PRAME+ Tumors with IMA203CD8, a PRAME-directed TCR T-cell Therapy: Results from a Phase 1 Study
Presenting Author: Antonia Busse, MD
Presentation Type: Proffered Paper presentation (oral presentation)
Session: Proffered paper: Investigational immunotherapy
Date / Time: October 23, 2026 / 13:30 – 15:00 CET
Presentation Number: 1946O
Title: Initial Results with IMA402 a PRAME-Targeted T-cell Receptor (TCR)-based Bispecific T-cell Engager (TCER) in Advanced Solid Tumors
Presenting Author: Dirk Schadendorf, MD
Presentation Type: Rapid Oral presentation
Session: Rapid oral: Investigational immunotherapy
Date / Time: October 24, 2026 / 08:30 – 10:00 CET
Presentation Number: 1955RO
About PRAME
PRAME is a target expressed in more than 50 cancers. Immatics is the global leader in precision targeting of PRAME and has the broadest PRAME franchise with the most PRAME indications and modalities. The Immatics PRAME franchise currently includes three product candidates, two therapeutic modalities and three combination therapies that target PRAME: anzu-cel (anzutresgene autoleucel, IMA203) PRAME cell therapy, IMA203CD8 PRAME cell therapy, IMA402 PRAME bispecific as monotherapy, in combination with immune checkpoint inhibitors, in combination with IMA401 MAGEA4/8 bispecific as well as anzu-cel in combination with Moderna’s PRAME mRNA designed to enhance cell therapy.
(Press release, Immatics, JUL 17, 2026, View Source [SID1234669301])