On March 31, 2017 Mateon Therapeutics, Inc. (OTCQX:MATN), a biopharmaceutical company developing vascular disrupting agents (VDAs) for the treatment of orphan oncology indications, reported that updates on several of its preclinical programs are being presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) annual meeting in Washington, D.C (Press release, Mateon Therapeutics, MAR 31, 2017, View Source [SID1234518365]).
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"These abstract presentations show the breadth of some of our early preclinical development programs," stated William D. Schwieterman, M.D., Mateon’s President and Chief Executive Officer. "As this work matures, we look forward to it complementing our current core clinical programs in platinum-resistant ovarian cancer and acute myeloid leukemia."
Poster presentations by Mateon and/or its collaborators at the AACR (Free AACR Whitepaper) annual meeting are as follows:
Abstract #2952 – The novel Cathepsin L/K inhibitors KGP94 and KGP207 prevent M0 to M2 macrophage differentiation and macrophage mediated pro-tumor functions.
Section: Tumor Microenvironment 3
Date and Time: Monday, April 3, 2017, 1:00 p.m. – 5:00 p.m. Eastern Time
Abstract #3203 – Targeting tumor hypoxia with prodrug conjugates of potent small molecule inhibitors of tubulin polymerization
Section: Novel Molecular Targets 2
Date and Time: Tuesday, April 4, 2017, 8:00 a.m. – 12:00 p.m. Eastern Time
Abstract #4899 – The small molecule Cathepsin L and K inhibitor KGP-94 impairs the metastatic phenotype of osteosarcoma cells
Section: Therapeutic Intervention of Cancer and Metastases
Date and Time: Tuesday, April 4, 2017, 1:00 p.m. – 5:00 p.m. Eastern Time
The above abstracts have been published and can be viewed on the AACR (Free AACR Whitepaper) Annual Meeting website.