On February 29, 2024 Medigene AG (Medigene, FSE: MDG1, Prime Standard), an immuno-oncology platform company focusing on the discovery and development of T cell immunotherapies for solid tumors, reported recent updates on the progress made within key areas of its proprietary End-to-End Platform, at the 7th CAR-TCR Summit Europe taking place in London from February 27-29, 2024 (Press release, MediGene, FEB 29, 2024, View Source [SID1234640683]).
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Data presented and discussed include
Barbara Lösch, Head of Technology & Innovation, spoke at a Seminar titled "Incorporating Modular Control into Cell Therapies through Receptors to Enhance Therapy Persistence & Safety". Options to boost specific efficacy at tumor site through modular control such as logic gating and switch receptors were discussed, including implementing a switch receptor to allow precise control of cells to minimize toxicity.
Dr. Dolores Schendel, Chief Scientific Officer of Medigene gave a presentation titled "Developing Effective Methods to Monitor, Track & Assess T-Cell Efficacy In Vivo & In Vitro". Prof. Schendel provided an overview of the Company´s proprietary End-to-End (E2E) Platform that has embedded a multitude of different technologies, providing solutions to overcome significant challenges in treating solid tumors and improving T cell receptor engineered T cell (TCR-T) therapies with respect to safety, efficacy and durability.
This presentation is available on Medigene’s website: View Source
Kirsty Crame, MD, VP Clinical Strategy & Development, participated in a panel discussion titled "Selecting the Right Indications to Ensure Successful Clinical Outcome", highlighting the importance of balancing multiple, potentially conflicting criteria, such as commercial viability and feasibility of patient recruitment in early phase trials, as critical to the potential success of an asset.
"The success of TCR-T therapies against solid tumors depends on three major areas of innovation, the generation of optimal safe, sensitive, and specific TCRs, tools to enhance engineered these T cells to overcome the suppressive tumor microenvironment, and finally strategies for TCR-T manufacturing that allow optimization of drug product composition and rapid delivery to the right patients", said Dolores Schendel, Chief Scientific Officer of Medigene. "With our E2E Platform, we provide solutions for all of these key areas, with innovation at multiple sequential steps of the discovery and development process. With our unique set of technologies, we are well positioned to provide new, best-in-class differentiated TCR-T therapies for treatment of patients with solid tumors."