On March 17, 2026 Onchilles Pharma, a private biotech company advancing therapeutics targeting the ELANE pathway, reported that new preclinical data supporting its systemically delivered NEU-002 program will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026, taking place April 17-22 in San Diego. The presentation will highlight the translational development of NEU-002, an engineered therapeutic elastase specifically designed for systemic administration, demonstrating anti-tumor activity via both intravenous and intraperitoneal delivery in solid tumors.
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"With our clinical-stage lead program, N17350, establishing the foundational proof-of-concept for the ELANE pathway, NEU-002 represents our second program and extends this approach into systemic delivery for solid tumors," said Court Turner, Co-Founder and Chief Executive Officer of Onchilles Pharma. "The data to be presented reflect our progress in engineering a systemically deliverable therapeutic that maintains anti-tumor activity and supports the advancement of NEU-002 toward development candidate selection and clinical translation."
Presentation Details
Title: Translational Development of NEU-002: Engineered Therapeutic Elastases Demonstrate Systemic Anti-Tumor Activity via Intraperitoneal and Intravenous Administration
Session Category: Experimental and Molecular Therapeutics
Session Title: Innovative Therapeutic Modalities and Translational Platforms
Day & Time: Saturday, April 19, from 2pm to 5pm PDT
Location: Poster Section 13
Poster Board Number: 28
Poster Number: 310
About Onchilles Therapeutic Programs Targeting the ELANE Pathway
At the core of this approach is the ELANE pathway, a unique cancer-selective killing mechanism that leverages a vulnerability shared by many cancer cell types: elevated histone H1 levels. Our pipeline is led by N17350, our first-in-class, clinical-stage program, followed by NEU-002, the second program that extends this approach with systemic delivery. By targeting the ELANE pathway and inducing immunogenic cancer cell death, N17350 and NEU-002 are designed to rapidly eliminate tumors while mobilizing an adaptive immune response, offering the potential for sustained anti-tumor immunity. N17350 and NEU-002 offer a unique approach to treating cancer regardless of their genetic makeup, anatomical origin, or immune status, positioning them as potential gamechangers in cancer therapy.
(Press release, Onchilles Pharma, MAR 17, 2026, View Source [SID1234663648])