Alpine Immune Sciences to Present at Jefferies 2018 Global Healthcare Conference

On May 22, 2018 Alpine Immune Sciences, Inc. (NASDAQ:ALPN), a company focused on discovering and developing innovative, protein-based immunotherapies targeting the immune synapse to treat cancer, autoimmune/inflammatory, and other diseases, reported the company will present at the Jefferies 2018 Global Healthcare Conference on Tuesday, June 5 2018 at 4:30 pm Eastern Time in New York, NY (Press release, Alpine Immune Sciences, MAY 22, 2018, View Source [SID1234526847]).

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A live webcast of the presentation will be available online in the investor relations section of the company’s website at View Source A replay of the presentation will be available on the company website for 90 days following the webcast.

AbbVie to Present at the Jefferies 2018 Global Healthcare Conference

On May 22, 2018 AbbVie (NYSE: ABBV), a research-based global biopharmaceutical company, reported it will participate in the Jefferies 2018 Global Healthcare Conference on Wednesday, June 6, 2018 (Press release, AbbVie, MAY 22, 2018, View Source [SID1234526846]). Bill Chase, executive vice president and chief financial officer, will present at 7:30 a.m. Central time.

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A live audio webcast of the presentation will be accessible through AbbVie’s Investor Relations website at investors.abbvie.com. An archived edition of the session will be available later that day.

DelMar Appoints Saiid Zarrabian to Full-Time President and CEO

On May 22, 2018 DelMar Pharmaceuticals, Inc. (the "Company")(NASDAQ: DMPI) reported that the board of directors (the "Board") has appointed Saiid Zarrabian as the full-time President and Chief Executive Officer of the Company, effective immediately (Press release, DelMar Pharmaceuticals, MAY 22, 2018, View Source [SID1234526845]). Mr. Zarrabian had previously served as the Company’s interim President and Chief Executive Officer since November 2017 and prior to that as an independent board member since July 2017.

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"Saiid has made significant contributions to DelMar, initially as an independent board member and, most recently, as DelMar’s interim President and CEO. We are pleased that he has agreed to further commit to the Company by taking on the full-time President and CEO role, effective immediately. His contributions have included a renewed focus on our two Phase 2 open label trials for MGMT-unmethylated glioblastoma multiforme, and enhanced fiscal responsibility while advancing our clinical programs in a timely and cost-effective fashion. The Board and I look forward to working with him to build on this momentum," stated Dr. Erich Mohr, Chairman of the Board.

"I am excited to transition from my interim role at DelMar and to continue the clinical advancement of VAL-083, which has been validated in over 40 prior clinical trials indicating VAL-083’s potential to combat multiple devastating diseases for patients with limited alternatives. Although VAL-083 may have applicability to many other solid tumor indications with potentially significant future commercial opportunities, we intend to use a disciplined and stepped approach to investing our resources in pursuing such opportunities. Over the next year, we expect to achieve a number of clinical milestones for VAL-083, including data from the ongoing Phase 2 second-line recurrent GBM study at MD Anderson, as well as data from the international Phase 2 study in newly diagnosed GBM patients. We plan to use our current capital efficiently and to continue to drive the enrollment of our clinical studies in an effort to maximize value for our shareholders," said Mr. Zarrabian.

Mr. Zarrabian is a successful veteran of the biotechnology industry. He previously served as chairman of the board of directors at La Jolla Pharmaceutical Company during the company’s transition from being an OTC listed company to a Nasdaq traded company. He also served as president of the Protein Production Division of Intrexon Corporation, a synthetic biology company. Prior to that, he served as chief executive officer and a member of the board of directors of Cyntellect, Inc., a stem cell processing and visualization instrumentation company until it was acquired in 2012. He served as president and chief operating officer of Senomyx, Inc., a company focused on discovery and commercialization of new flavor ingredients, and as chief operating officer of Pharmacopeia, Inc., a former publicly-traded provider of combinatorial chemistry discovery services and compounds, where he also served as president and chief operating officer of its MSI Division. In addition, Mr. Zarrabian has served on numerous private and public company boards, including at Immune Therapeutics, Inc., Exemplar Pharma, LLC, Ambit Biosciences Corporation, eMolecules, Inc. and Penwest Pharmaceuticals Co. Currently, he is serving as an advisor to Redline Capital Partners, S.A., a Luxemburg-based investment firm.

CoBioRes receives a € 1.7M grant from VLAIO to support its tetrapeptide prodrug research for treatment of Triple Negative Breast Cancer

On May 22, 2018 CoBioRes NV, an early stage biotech company that valorises promising academic research in the field of medicine by translating it into innovative therapeutic approaches, reported that it has received a € 1.7 million R&D grant from Flanders Innovation and Entrepreneurship (VLAIO) (Press release, Collaborative Biotech Research, MAY 22, 2018, View Source [SID1234526842]). This grant will allow CoBioRes to further develop and to select a lead Tetra-doxo candidate (doxorubicin prodrug) for treatment of Triple Negative Breast Cancer (TNBC) based on in vivo efficacy and toxicity testing. Furthermore, potential new biomarkers will be investigated.

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Approximately 12% of all breast cancers are triple negative. In TNBC the growth of the cancer is not supported by the hormones estrogen and progesterone, nor characterised by the presence of many HER2 receptors. Therefore, TNBC does not respond to hormonal therapy or therapies that target HER2 receptors, such as trastuzumab (Herceptin). There’s a clear need for new effective treatments in this large patient population.

"We are very pleased to receive this support from VLAIO. This will enable the company to obtain in vivo proof-of-concept of its Tetra-doxo prodrugs and to identify new biomarkers for patient selection. This will pave the way for initiation of further preclinical and clinical development," said dr. Nele Kindt, CEO at CoBioRes.

About Tetra-prodrugs technology
Use of traditional chemotherapeutic drugs is restricted by severe side effects and lack of tumour specificity. CoBioRes has designed a tumour-specific activation system by chemically linking a cap and a specific oligopeptide to a chemotherapeutic drug, rendering the modified drug inactive and blocking systemic toxic side effects of the drug. The chemotherapeutic prodrugs are activated by selective proteases available in the tumour microenvironment. This leads to a precise control of drug activation and release, circumventing distribution of native active drugs in other tissues. This finally leads to a combination of selective efficacy and reduced systemic toxicity, resulting in an improved therapeutic index.

Immunocore to Present New Data from IMCgp100-102 Trial in Metastatic Uveal Melanoma at 2018 ASCO Annual Meeting

On May 22, 2018 Immunocore Limited, a leading T cell receptor (TCR) company focused on delivering first-in-class biological therapies that have the potential to transform lives, reported that new data from its phase I/II dose escalation trial of its wholly-owned, lead programme, IMCgp100, in metastatic uveal melanoma (mUM) will be presented at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting in Chicago on 4 June 2018 (Press release, Immunocore, MAY 22, 2018, View Source [SID1234526841]).

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Redirected T cell lysis in patients with metastatic uveal melanoma with gp100-directed TCR IMCgp100: Overall survival findings (abstract 9521, poster #348) will be presented by Takami Sato, MD, PhD, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, in the melanoma/skin cancers poster session on Monday 4 June, 13:15-16:45 CDT. The poster presentation will include updated data and additional findings from the IMCgp100-102 clinical trial.

"Patients with metastatic uveal melanoma have an extremely rare form of eye cancer and there are currently few treatment options that can address their needs," said Dr. Chris Coughlin, Chief Medical Officer at Immunocore. "We are actively recruiting for our pivotal trials in metastatic uveal melanoma, and are looking forward to sharing updated overall survival data from our IMCgp100-102 study at this year’s ASCO (Free ASCO Whitepaper) meeting."