On November 30, 2023 Peptone, a leader in translational biophysics and the design of novel therapeutics against intrinsically disordered proteins (IDPs), and The Institute of Oncology Research (IOR) reported the commencement of a collaborative sponsored research agreement in prostate cancer (Press release, The lOR Institute of Oncology Research, NOV 30, 2023, View Source [SID1234638079]). The collaboration will focus on the identification and progression of novel targets in oncology using translational models to develop innovative medicines for patients suffering from prostate cancer.
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"A collaboration with IOR combines Peptone’s unique expertise targeting disordered proteins with the power of generative machine learning, unique structural insights into disordered targets and patient insights about cancer born out of seminal work from Professor Alimonti’s group in Bellinzona," said Kamil Tamiola, PhD, CEO of Peptone. "Our collaboration is an excellent example of efficient technology transfer process and a burgeoning research and biotech ecosystem in Ticino, Switzerland."
Peptone is applying advanced biophysics atomic-level experimental approaches, including a novel ultra-low latency hydrogen-deuterium exchange mass spectrometry (HDX-MS), supercomputing and generative AI to interrogate and drug intrinsically disordered proteins (IDPs). IDPs are proteins that play a significant role in health and disease but because they lack a fixed structure, have been intractable or undruggable with conventional drug discovery approaches.
"Prostate cancer remains a highly prevalent disease with significant unmet clinical needs," said Professor Andrea Alimonti, MD, Incoming Director, and Professor of Molecular Oncology at IOR. "We are delighted to partner with Peptone on this research collaboration focused on novel target discovery in prostate cancer. Recent findings from my team demonstrate that advanced prostate cancer is regulated by several intrinsically disordered proteins, many of which can also control the tumor immune response. Targeting these proteins is a promising approach to this challenging disease."