On November 9, 2020 Surface Oncology (Nasdaq: SURF), a clinical-stage immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, reported that preclinical data on SRF388, a first in class IL-27 blocking antibody in clinical trials for patients with cancer, and SRF114, a CCR8-selective antibody, will be presented at the Society for Immunotherapy for Cancer’s (SITC) (Free SITC Whitepaper) 35th Anniversary Annual Meeting, which will be held virtually on November 11–14, 2020 (Press release, Surface Oncology, NOV 9, 2020, View Source [SID1234570316]).
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"These data demonstrate single agent activity of SRF388 in a mouse model of hepatocellular carcinoma, or HCC, and identify candidate biomarkers associated with IL-27 blockade. Moreover, serum levels of the IL-27 subunit EBI3 were found to be elevated in many patients with HCC and associated with poor prognoses, highlighting the importance of this cytokine in a difficult to treat cancer," said Vito Palombella, chief scientific officer. "Compelling preclinical data for SRF114 will also be presented; these data demonstrate highly-selective CCR8 binding and depletion of tumor regulatory T cells. We are very encouraged by these data as we continue to advance both programs."
Summaries are provided below; full posters will be placed on Surface Oncology’s website following the start of the presentation.
Details of Surface’s SITC (Free SITC Whitepaper) presentations:
Session Title: Virtual Poster Hall Session
Presentation Title: Increased Serum Levels of EBI3 Are Associated with Poor Outcome in Hepatocellular Carcinoma Patients and SRF388, a First-in-Class IL-27 Blocking Antibody, Inhibits the Growth of Murine Liver Tumors
Lead Author: Matthew Rausch, Ph.D.
Session Date and Time: Wednesday, November 11, 2020, 9:00 a.m. ET
Summary:
•SRF388 is a monoclonal antibody designed to inhibit the immuno-suppressive cytokine IL-27.
•Circulating levels of the EBI3 subunit of IL-27 are elevated in a subset of patients with HCC and inversely correlated with overall survival.
•SRF388 enhances proinflammatory cytokine production in combination with PD-1 blockade in vitro in activated peripheral blood mononuclear cells from healthy donors and patients with HCC. Furthermore, SRF388 demonstrates single-agent activity in vivo in a murine orthotopic model of HCC.
Session Title: Virtual Poster Hall Session
Presentation Title: SRF114 is a Fully Human, CCR8-Selective IgG1 Antibody that Induces Destruction of Tumor Tregs Through ADCC
Lead Author: Andrew C. Lake, Ph.D.
Session Date and Time: Wednesday, November 11, 2020, 9:00 a.m. ET
Summary:
•Targeting CCR8 with SRF114 causes depletion of intra-tumoral Tregs, important regulators of peripheral immune tolerance, through ADCC.
•SRF114 is highly selective for CCR8; no off-target binding was identified following extensive screening.
About SRF388:
SRF388 is a fully human anti-IL-27 antibody designed to inhibit the activity of this immunosuppressive cytokine. Surface Oncology has identified particular tumor types, including hepatocellular and renal cell carcinoma, where IL-27 appears to play an important role in the immunosuppressive tumor microenvironment and may contribute to resistance to treatment with checkpoint inhibitors. Furthermore, Surface Oncology has identified a potential biomarker associated with IL-27 that may be useful in helping identify patients most likely to respond to SRF388.
About SRF114:
SRF114 is a monoclonal antibody targeting the chemokine receptor CCR8. SRF114 is a highly-specific antibody that drives the tumor-specific depletion of immuno-suppressive T regulatory cells.