On September 29, 2017 Syros Pharmaceuticals (NASDAQ: SYRS), a biopharmaceutical company pioneering the discovery and development of medicines to control the expression of disease-driving genes, reported that the Company will present biomarker data from its ongoing Phase 2 clinical trial of SY-1425, an oral first-in-class selective retinoic acid receptor alpha (RARα) agonist, in genomically defined subsets of patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) at the European School of Haematology’s 4th International Conference on Acute Myeloid Leukemia “Molecular and Translational”: Advances in Biology and Treatment taking place October 5-7 in Estoril, Portugal (Press release, Syros Pharmaceuticals, SEP 29, 2017, View Source [SID1234520706]).

The presentation will describe Syros’ proprietary RARA and IRF8 biomarkers, including their prevalence in AML and MDS patients screened for enrollment in the Phase 2 clinical trial to date. The presentation will also include data correlating biomarker status with myeloid differentiation in cells taken from patients upon screening for the trial and then treated ex vivo with SY-1425.

Details on the presentations are as follows:

Date & Time: Friday, October 6, from 7:05 – 8:30 p.m. WEST (2:05 -3:30 p.m. EDT)
Presentation Title: Novel RARA Pathway Activation Biomarkers in Study SY-1425-201 Define a New Subset of AML and MDS Patients and Correlate with Myeloid Differentiation Following Ex Vivo SY-1425 Treatment
Session Title: Molecular Therapeutics
Presenter: Emmanuelle di Tomaso, Ph.D., Vice President, Translational Medicine, Syros
Abstract Number: 8882
Location: Estoril Congress Centre