On September 19, 2017 Advaxis, Inc. (NASDAQ: ADXS), a late-stage biotechnology company focused on the discovery, development and commercialization of immunotherapy products, reported two abstracts were selected for presentation at the 32nd annual Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) meeting (Press release, Advaxis, SEP 19, 2017, View Source [SID1234520564]). The conference is renowned for its scientific exchange, education and mission to improve patient outcomes through advancement of science and the cancer immunotherapy field.
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Both poster presentations feature Advaxis’ proprietary Listeria monocytogenes (Lm)-based technology. The first presentation, "ADXS-PSA immunotherapy increases the magnitude and quality of prostate cancer antigen-specific T cell responses in patients with metastatic castration-resistant prostate cancer," will feature data from Advaxis’ clinical trial with ADXS-PSA. The presentation examines the frequency and functionality of the T cell response not only specific to its target antigen, but to other prostate cancer antigens.
This data builds on what was presented at CICON 2017 and is the first time that an Lm-based vector targeting a self protein – PSA – can increase the frequency and functionality of T cells reactive to PSA as well as to other prostate cancer antigens. As one of Advaxis’ four focus franchises, prostate cancer could be a significant value creator to expand the Lm platform into new tumor types. The data will be presented by Sandy Hayes, Ph.D., senior director of research and biomarker lead at Advaxis.
The second poster presentation, "Listeria monocytogenes-based immunotherapies alter the suppressive phenotype of intratumoral regulatory T cells," spotlights preclinical data pointing to a potential key mechanism for inducing and sustaining infiltration of tumor-specific T cell effectors. The data will be presented by Rachelle E. Kosoff, Ph.D., senior scientist of research at Advaxis.
"We’re grateful to be sharing these meaningful findings with the rest of the immunotherapy community," said Dr. Robert Petit, chief scientific officer at Advaxis. "Each poster presentation allows members of our field to discuss new findings and approaches, with the goal of bringing improved treatment options to patients."
SITC takes place at Maryland’s National Harbor in the Gaylord National Hotel and Convention Center from Nov. 8 – 12, 2017. The conference focuses on improving outcomes for current and future patients with cancer by incorporating strategies based on basic and applied immunotherapy.
To learn more about Advaxis and its immunotherapy clinical programs, visit www.advaxis.com/clinical-trials.