On November 4, 2026 Verismo Therapeutics, a clinical-stage CAR T cell therapy company pioneering a novel multi-chain KIR-CAR platform technology, reported that clinical data from its ongoing Phase 1 CELESTIAL-301 trial (NCT06544265) of SynKIR-310 have been selected for an oral presentation at the 68th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition, taking place December 12-15, 2026, in New Orleans. The oral presentation will include updated clinical and pharmacokinetic/pharmacodynamic correlative data across SynKIR-310 dose cohorts 1 through 3 in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) following at least two prior lines of therapy.

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In the initial clinical readout, SynKIR-310 showed an 80% objective response rate (4 of 5 evaluable patients) and a 60% complete response rate across dose cohorts 1 and 2, and the median duration of response in patients with a complete response was not reached with one patient in continued complete response at the 12-month assessment. No cytokine release syndrome (CRS) or immune effector cell-associated neurotoxicity syndrome (ICANS) of any grade was reported in any patient treated at the first two dose levels, and no dose-limiting toxicities were observed. Three of the six treated patients received SynKIR-310 in the outpatient setting. Additional data will be presented at the ASH (Free ASH Whitepaper) 2026 oral session in December.

Verismo will also present two additional preclinical poster abstracts — a novel CD19/CD20 dual-targeted KIR-CAR and a head-to-head preclinical comparison of SynKIR-310 against single-chain CAR T designs. The dual-targeted construct (Yucel et al.) addresses antigen heterogeneity — a leading cause of relapse after conventional CD19 CAR T — and shows substantially reduced cytokine levels versus a single-chain benchmark. In the head-to-head comparison (Blair et al.), SynKIR-310 achieved deeper tumor control than single-chain CD19 CAR T designs with substantially lower cytokine production.

ASH 2026 — Clinical Oral Presentation

Title: First-in-human evaluation of SynKIR-310 employing a novel multi-chain KIR-based CAR demonstrates promising antitumor activity and no reported CRS or ICANS in patients with high-risk B-NHL
Presenter: Michael Tees, M.D., Colorado Blood Cancer Institute
Session: 704. Cellular Immunotherapies: Early Phase Clinical Trials and Toxicities
Session Date and Time: Dec 13, 2026: 5:45 – 6:00 PM
Location: Ernest N. Morial Convention Center, New Orleans, Louisiana
Publication Number: 708
Full Abstract: View Source
Full Clinical Data Readout: Released at the time of presentation

ASH 2026 — Preclinical Poster Presentations

Poster 1 — Novel CD19/CD20 Dual-Targeted KIR-CAR
Title: CD19/20 dual targeted killer immunoglobulin-like receptor (KIR)-based CAR T eliminates antigen-heterogenous B cell lymphomas with reduced cytokine secretion and adaptable ex vivo or in vivo gene delivery
Presenter: Nora Yucel, Ph.D., Verismo Therapeutics
Session: 702. CAR-T Cell Therapies: Basic and Translational
Session Date and Time: Dec 14, 2026: 6 – 8 PM
Full Abstract: View Source

Poster 2 — SynKIR-310 vs. Single-Chain CAR T Preclinical Comparison
Title: CD19-targeted multi-chain killer immunoglobulin receptor (KIR)-based CAR T demonstrate an enhanced benefit-risk profile over single-chain CAR T
Presenter: Megan Blair, Ph.D., Verismo Therapeutics
Session: 703. Cellular Immunotherapies other than CAR-T Cells: Basic and Translational
Session Date and Time: Dec 14, 2026: 6 – 8 PM
Full Abstract: View Source

About the KIR-CAR Platform

The KIR-CAR platform is a multi-chain T cell therapy that has shown highly effective solid tumor treatment in otherwise CAR-resistant animal models with hard-to-treat tumors. Using NK cell-derived killer immunoglobulin-like receptor (KIR) and DAP12 to split the target binding and T cell activation signals provides a novel paired immune-receptor activation that is independent from CD3 signaling and does not require additional co-stimulation. KIR-CAR enables sustained cell receptor expression in T cells, and induces deeper, more durable tumor treatments. Together, this multi-chain cell signaling platform provides the potential to deliver effective patient treatments by minimizing the background activation and early T cell exhaustion observed in conventional single-chain CAR T therapy, with potential to treat patients with both solid and hematologic tumors. The KIR-CAR platform is adaptable to both ex vivo and in vivo delivery modalities.

(Press release, Verismo Therapeutics, NOV 4, 2026, View Source [SID1234674223])