On November 4, 2021 Viracta Therapeutics, Inc. (Nasdaq: VIRX), a precision oncology company primarily focused on targeting virus-associated malignancies, reported the acceptance of two abstracts for oral presentation and one for a poster presentation at the upcoming 2021 American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting, which will be held from December 11-14, 2021, both in Atlanta, Georgia and virtually (Press release, Viracta Therapeutics, NOV 4, 2021, View Source [SID1234594355]).
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"We are thrilled that the final results from our Phase 1b/2 trial in relapsed/refractory EBV positive lymphoma have been selected for an oral presentation at ASH (Free ASH Whitepaper), and we are pleased to see our presence expand this year to include an additional asset from our portfolio," said Ivor Royston, M.D., President and Chief Executive Officer of Viracta. "Having three abstracts accepted at ASH (Free ASH Whitepaper) is an honor that we believe speaks to the innovative nature of our growing pipeline. We look forward to the meeting in December and are excited to share more about these programs following the presentations."
Details on the abstracts, which have been published on the ASH (Free ASH Whitepaper) website, are shown below:
Nanatinostat (Nstat) and Valganciclovir (VGCV) in Relapsed/Refractory (R/R) Epstein-Barr Virus-Positive (EBV+) Lymphomas: Final Results from the Phase 1b/2 VT3996-201 Study (Publication #623)
Session Name: 624. Hodgkin Lymphomas and T/NK cell Lymphomas: T/NK Cell Lymphoma Relapsed Therapy
Session Date: Monday, December 13, 2021
Session Time: 10:30 AM – 12:00 PM ET
Presentation Time: 11:30 AM ET
Presentation Type: Oral
Room: Georgia World Congress Center, Hall A1
Final results from Viracta’s Phase 1b/2 trial evaluating Nana-val in R/R EBV+ lymphoma will be presented. Data from the trial indicate that Nana-val was well tolerated and showed promising efficacy.
Enhanced CAR T cell activity with non-covalent BTK/ITK inhibition (Publication #906)
Session Name: 703. Cellular Immunotherapies: Basic and Translational IV
Session Date: Monday, December 13, 2021
Session Time: 6:15 PM – 7:45 PM ET
Presentation Time: 7:30 PM ET
Presentation Type: Oral
Room: Georgia World Congress Center, Hall A1
Data to be featured in the oral presentation relate to vecabrutinib, a selective, reversible, non-covalent inhibitor of Burton’s tyrosine kinase (BTK) and interleukin-2-inducible kinase (ITK). These data demonstrate that using vecabrutinib is a novel strategy to modulate CD19-targeted chimeric antigen receptor (CAR) T cell functions by increasing their efficacy, and decreasing their toxicity, while maintaining their proliferative potential.
Efficacy of Vecabrutinib Treatment in a Murine Model of Sclerodermatous Graft-Versus-Host-Disease (Publication #1685)
Session Name: 701. Experimental Transplantation: Basic and Translational: Poster I
Session Date: Saturday, December 11, 2021
Presentation Time: 5:30 – 7:30 PM ET
Presentation Type: Poster
Location: Georgia World Congress Center, Hall B5
The poster presentation will feature data showing that vecabrutinib treatment demonstrated efficacy and beneficially regulated B cell and T cell immune subsets in a preclinical murine model of sclerodermatous chronic graft-versus-host disease.
Copies of the poster and oral presentations will be available on the "Events and Webcasts" section of the Viracta website at View Source following their presentation at the meeting.
About Nanatinostat
Nanatinostat (VRx-3996) is an orally available histone deacetylase (HDAC) inhibitor being developed by Viracta. Nanatinostat is selective for specific isoforms of Class I HDACs, which is key to inducing viral genes that are epigenetically silenced in EBV-associated malignancies. Nana-val (nanatinostat and valganciclovir) is being investigated in multiple subtypes of relapsed/refractory EBV+ lymphoma and in advanced EBV+ solid tumors in three ongoing trials, one of which is a registration-enabling global, multicenter, open-label Phase 2 basket trial in relapsed/refractory EBV+ lymphoma (NAVAL-1).
About Vecabrutinib
Vecabrutinib is a selective, reversible, non-covalent inhibitor of Burton’s tyrosine kinase (BTK) and interleukin-2-inducible kinase (ITK). Vecabrutinib is being studied as a potential enhancer of efficacy and safety of CAR T cell therapy.