On September 23, 2026 Xspray Pharma reported that data on its two product candidates Dasynoc and Nilopki have been accepted for poster presentation at the ESH-iCMLf 28th Annual John Goldman Conference on Chronic Myeloid Leukemia, taking place in Gothenburg, Sweden, on 2-4 October 2026.
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The two posters focus on clinically relevant limitations of today’s tyrosine kinase inhibitor, TKI, treatments in CML and how Xspray’s HyNap formulation technology may help address them. For patients and physicians, the findings point to the possibility of more predictable exposure and thereby improved management of safety risks. For Xspray, the data further support the differentiated profiles of Dasynoc and Nilopki and their potential roles as improved formulations of established CML therapies.
"Xspray is utilizing its HyNap technology platform and scientific capabilities to unlock the full potential of these molecules through strong collaboration with leading key opinion leaders. I am incredibly proud of Chief Scientific Officer Per Andersson and the entire Xspray team for their leadership and achievements as we execute on our strategy and advance our portfolio," commented Xspray’s CEO Blake Leitch.
Two internationally renowned CML-specialists, Professor Michael J. Mauro and Professor Jorge Cortes, were co-authors of the poster abstracts and gave the following comments:
"The formulation technology utilised in Dasynoc/XS004 has the potential to provide an ideal basis for a low dose treatment algorithm with dasatinib; this could improve the management of CML patients substantially" said Professor Michael Mauro, director of the Chronic Myeloid Leukemia Program at Memorial Sloan Kettering Cancer Center in New York, USA and Professor of Medicine at Weill Cornell Medical College.
"The elimination of food effect can provide an improved safety profile, of nilotinib particularly the cardiac risk profile, and thereby reduce the risk to patients and the uncertainty for both patients and care givers," said Professor Jorge Cortes, Chief of Hematology in the Division of Hematology and Oncology at the University of Alabama at Birmingham, UAB, and Deputy Director of the O’Neal Cancer Center at UAB.
The poster presentations add to the growing body of data supporting Xspray’s HyNap technology platform and its potential to create improved formulations of established targeted cancer therapies. For Dasynoc and Nilopki, the findings are relevant both from a clinical perspective, by addressing known safety and dosing challenges in CML treatment, and from a commercial perspective, by supporting differentiated product profiles in large and well-established treatment categories.
Dasynoc: a more predictable, lower-dose approach to dasatinib
The first poster sets out why Dasynoc may improve the tolerability of dasatinib while maintaining its effect. Tolerability and clinical effect depend on different pharmacokinetic parameters: trough concentration is linked to pleural effusion, a build-up of fluid around the lungs and effects tolerability. Whereas clinical efficacy tracks overall drug exposure in the blood. Because exposure varies widely with crystalline dasatinib, reducing the dose risks subtherapeutic levels in some patients.
Dasynoc’s markedly lower variability may allow a lower dose that still works for the individual patient: fewer patients exposed to the high levels linked to pleural effusion, and fewer left below the level for desired clinical effect.
Nilopki: reduced food effect may lower cardiovascular safety uncertainty
The second poster concerns Nilopki/XS003, Xspray’s formulation of nilotinib. The abstract investigates the relationship between nilotinib plasma exposure and cardiovascular adverse events. The data indicate that Nilopki avoids the food-induced increase in plasma exposure seen with crystalline nilotinib. In addition, the estimated effect on the QTc interval decreases under fed conditions with Nilopki, while it increases with crystalline nilotinib.
This is clinically relevant because nilotinib treatment is associated with cardiovascular safety considerations, and food intake may contribute to increased plasma exposure with conventional crystalline nilotinib. Conventional crystalline nilotinib, either in the form of Tasigna or generic versions, patients must avoid food for two hours before and one hour after each twice-daily dose. By reducing the food effect, Nilopki may offer a more predictable treatment profile and reduce uncertainty in everyday use.
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Xspray will also present and discuss the two poster announcements at a live-streamed Investor Update in Gothenburg on 2 October 2026, starting 12.30 CET. The Investor Update will provide an opportunity to place the new data in the broader context of Xspray’s clinical, regulatory and commercial strategy for Dasynoc and Nilopki.
(Press release, Xspray, SEP 23, 2026, View Source [SID1234671033])